Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
ɫ ɩɨ ɝɝ Ⱦɠɨɧ ɏɨɥɬ ɢ ɝɥɚɜɧɵɣ ɫɭɞɶɹ Ⱥɧɝɥɢɢ ɫ ɩɨ ɝɝ Ɇɷɧɫɮɢɥɞ ɨɬɫɬɚɢɜɚɥɢ ɧɟɨɛɯɨɞɢɦɨɫɬɶ ɫɭɳɟɫɬɜɟɧɧɨɝɨ ɜɤɥɸɱɟɧɢɹ OH[ PHUFDWRULD ɜ ɨɛɳɟɟ ɩɪɚɜɨ ɢ ɫɨɝɥɚɫɨɜɚɧɢɹ ɷɬɢɯ ɞɜɭɯ ɫɢɫɬɟɦ ɬɚɤ ɢ ɫɟɝɨɞɧɹ OH[ VSRUWLYD ɫɥɨɠɧɵɦ ɨɛɪɚɡɨɦ ɜɡɚɢɦɨɞɟɣɫɬɜɭɟɬ ɫ ɫɚɧɤɰɢɨɧɢɪɨɜɚɧɧɵɦ ɝɨɫɭɞɚɪɫɬɜɨɦ ɤɨɦɩɥɟɤɫɨɦ ɧɨɪɦɚɬɢɜɧɵɯ ɩɪɚɜɨɜɵɯ ɭɫɬɚɧɨɜɥɟɧɢɣ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ± ɫɩɨɪɬɢɜɧɵɦ ɩɪɚɜɨɦ
Ⱥ Ⱥ ɋɨɥɨɜɶɺɜ ɩɪɢɜɨɞɢɬ ɜ ɩɪɢɦɟɪ ɢɬɚɥɶɹɧɫɤɢɟ ɫɩɨɪɬɢɜɧɵɟ ɤɨɞɟɤɫɵ ɫɨ ɫɦɟɲɚɧɧɨɣ ɧɨɪɦɚɬɢɜɧɨɣ ɩɪɢɪɨɞɨɣ ± ɩɪɚɜɨɜɨɣ ɢ ɜɧɟɩɪɚɜɨɜɨɣ OH[ VSRUWLYD ± Ʉɨɞɟɤɫ ȼɵɫɲɟɝɨ ɋɭɞɚ ɫɩɨɪɬɢɜɧɨɣ ɸɫɬɢɰɢɢ ɢ Ʉɨɞɟɤɫ ɇɚɰɢɨɧɚɥɶɧɨɝɨ ɫɩɨɪɬɢɜɧɨɝɨ ɚɪɛɢɬɪɚɠɧɨɝɨ ɬɪɢɛɭɧɚɥɚ
Ɂɧɚɱɟɧɢɟ ɜɥɢɹɧɢɹ ɫɩɨɪɬɢɜɧɨɝɨ ɩɪɚɜɚ ɧɚ OH[ VSRUWLYD ɧɟ ɫɥɟɞɭɟɬ ɧɟɞɨɨɰɟɧɢɜɚɬɶɂɦɟɧɧɨɫɩɨɪɬɢɜɧɨɟɩɪɚɜɨɩɪɢɞɚɥɨɫɨɜɪɟɦɟɧɧɨɦɭɫɩɨɪɬɭ ɬɨɬ ɟɝɨ ɫɥɨɠɧɨɫɬɪɭɤɬɭɪɧɵɣ ɢ ɦɧɨɝɨɚɫɩɟɤɬɧɵɣ ɜɢɞ ɤɚɤɨɣ ɦɵ ɦɨɠɟɦ ɥɢɰɟɡɪɟɬɶ ɫɟɝɨɞɧɹ
Ɏɢɥɢɩɩ ɀɟɫɬɚғɫɩɪɚɜɟɞɥɢɜɨ ɩɨɞɱɺɪɤɢɜɚɥ ɱɬɨ ©ɛɟɡ ɧɨɪɦɚɬɢɜɧɨ ɩɪɚɜɨɜɨɣ ɫɢɫɬɟɦɚɬɢɡɚɰɢɢ ɫɩɨɪɬ ɜ ɧɨɜɟɣɲɟɣ ɢɫɬɨɪɢɢ ɬɚɤ ɢ ɧɟ ɩɪɟɨɞɨɥɟɥ ɛɵ ³ɞɜɨɣɧɭɸ ɫɩɥɨɲɧɭɸ´ ɞɨɫɭɝɚ ɜ ɤɨɥɥɟɞɠɚɯ ɢɝɪ ɢ ɪɚɡɜɥɟɱɟɧɢɣª
ȼɫɩɨɦɧɢɦ ɢ ɡɧɚɱɟɧɢɟ ɲɜɟɣɰɚɪɫɤɨɝɨ ɧɚɰɢɨɧɚɥɶɧɨɝɨ ɩɪɚɜɚ ɜ ɨɬɧɨɲɟɧɢɢ ɫɬɚɬɭɫɚ Ɇɟɠɞɭɧɚɪɨɞɧɨɝɨ ɫɩɨɪɬɢɜɧɨɝɨ ɚɪɛɢɬɪɚɠɧɨɝɨ ɫɭɞɚ ɜ ɝ Ʌɨɡɚɧɧɚ ɚ ɬɚɤɠɟ ɫɢɬɭɚɰɢɸ ɫ ɨɩɪɟɞɟɥɹɸɳɢɦ ɜɨɡɞɟɣɫɬɜɢɟɦ ɪɟɲɟɧɢɹ ȿɜɪɨɩɟɣɫɤɨɝɨ ɫɭɞɚ ɫɩɪɚɜɟɞɥɢɜɨɫɬɢ ɩɨ ɞɟɥɭ Ȼɨɫɦɚɧɚ ɧɚ ɫɢɫɬɟɦɭ ɎɂɎȺ
ɋɟɝɨɞɧɹ ɟɫɬɶ ɦɧɨɠɟɫɬɜɨ ɫɜɢɞɟɬɟɥɶɫɬɜ ɬɨɦɭ ɱɬɨ ɝɨɫɭɞɚɪɫɬɜɨ ɞɟ ɮɚɤɬɨ ɢ ɞɟ ɸɪɟ ɩɪɢɡɧɚɺɬ OH[ VSRUWLYD
ɇɚɢɛɨɥɟɟ ɹɪɤɢɦɢ ɩɪɢɦɟɪɚɦɢ ɤɨɪɪɟɥɢɪɨɜɚɧɢɹ ɢ ɢɧɬɟɪɮɟɪɟɧɰɢɢ ɫɩɨɪɬɢɜɧɨɝɨ ɩɪɚɜɚ ɢ OH[ VSRUWLYD ɤɨɝɞɚ ɝɨɫɭɞɚɪɫɬɜɨ ɩɪɢɡɧɚɺɬ ɢ ɥɟɝɢɬɢɦɢɡɢɪɭɟɬ ɞɟɣɫɬɜɢɟ OH[ VSRUWLYD ɟɝɨ ɩɪɢɨɪɢɬɟɬ ɢ ɟɝɨ ɛɨɥɟɟ ɜɵɫɨɤɭɸ ɫɢɥɭ ɩɟɪɟɞ ɫɩɨɪɬɢɜɧɵɦ ɩɪɚɜɨɦ ɩɨ ɨɩɪɟɞɟɥɺɧɧɨɦɭ ɤɪɭɝɭ ɜɨɩɪɨɫɨɜ ɬɟɦ ɫɚɦɵɦ ɮɚɤɬɢɱɟɫɤɢ ɫɚɧɤɰɢɨɧɢɪɭɹ ɜ ɪɚɡɥɢɱɧɨɣ ɫɬɟɩɟɧɢ ɧɨɪɦɚɬɢɜɧɭɸ ɫɢɥɭ ɨɬɞɟɥɶɧɵɯ ɧɨɪɦɚɬɢɜɧɵɯ ɤɨɦɩɥɟɤɫɨɜ ɢɡ OH[ VSRUWLYD ɹɜɥɹɸɬɫɹ ɫɥɟɞɭɸɳɢɟ
ɹɪɱɚɣɲɢɣ ɩɪɢɦɟɪ ± ɢɦɩɥɟɦɟɧɬɚɰɢɹ ɧɨɪɦɚɬɢɜɧɵɯ ɭɫɬɚɧɨɜɥɟɧɢɣ ɢ ɬɪɟɛɨɜɚɧɢɣ ɎɂɎȺ ɢɥɢ ɍȿɎȺ ɜ ɧɚɰɢɨɧɚɥɶɧɨɟ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɨ ɩɪɢ ɩɪɨɜɟɞɟɧɢɢ ɑɟɦɩɢɨɧɚɬɚ ȿɜɪɨɩɵ ɩɨ ɮɭɬɛɨɥɭ ɍȿɎȺ Ʉɭɛɤɚ ɤɨɧɮɟɞɟɪɚɰɢɣ ɩɨ ɮɭɬɛɨɥɭ ɩɨɞ ɷɝɢɞɨɣ ɎɂɎȺ ɢ ɑɟɦɩɢɨɧɚɬɚ ɦɢɪɚ ɩɨ ɮɭɬɛɨɥɭ ɎɂɎȺ ɩɪɢɬɨɦ ɱɬɨ ɋɨɸɡ ɟɜɪɨɩɟɣɫɤɢɯ ɮɭɬɛɨɥɶɧɵɯ ɚɫɫɨɰɢɚɰɢɣ ɚɧɝɥ 8QLRQ RI (XURSHDQ )RRWEDOO $VVRFLDWLRQV ɫɨɤɪ 8()$ ɜ ɪɭɫɫɤɨɣ ɬɪɚɧɫɥɢɬɟɪɚɰɢɢ ɍȿɎȺ ɢ
/H[ PHUFDWRULD KWWS ZZZ DQVZHUV FRP WRSLF ODZ PHUFKDQW!
ɋɨɥɨɜɶɺɜ Ⱥ.Ⱥ. Ɋɨɫɫɢɣɫɤɢɣ ɢ ɡɚɪɭɛɟɠɧɵɣ ɨɩɵɬ ɫɢɫɬɟɦɚɬɢɡɚɰɢɢ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɚ ɨ ɫɩɨɪɬɟ Ʉɨɦɢɫ ɩɨ ɫɩɨɪɬ ɩɪɚɜɭ Ⱥɫɫɨɰ ɸɪɢɫɬɨɜ Ɋɨɫɫɢɢ ± Ɇ ± ɫ ± ɋJestaz P. 6SHFWDFOH VSRUWLI HW 'URLW GX VSRUW >ɋɩɨɪɬɢɜɧɨɟ ɡɪɟɥɢɳɧɨɟ ɩɪɟɞɫɬɚɜɥɟɧɢɟ ɢ ɫɩɨɪɬɢɜɧɨɟ ɩɪɚɜɨ@ /H VSHFWDFOH VSRUWLI 3XEOLFDWLRQ GH OD )DFXOWp GH 'URLW HW GHV 6FLHQFHV (FRQRPLTXHV GH O¶8QLYHUVLWp GH /LPRJHV &HQWUH GH 'URLW HW G¶(FRQRPLH GX 6SRUW ± 3DULV 38)
± S ± 3
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
Ɇɟɠɞɭɧɚɪɨɞɧɚɹ ɮɭɬɛɨɥɶɧɚɹ ɮɟɞɟɪɚɰɢɹ ɮɪ )pGpUDWLRQ LQWHUQDWLRQDOH GH IRRWEDOO DVVRFLDWLRQ ɫɨɤɪ ),)$ ɜ ɪɭɫɫɤɨɣ ɬɪɚɧɫɥɢɬɟɪɚɰɢɢ ɎɂɎȺ ± ɷɬɨ ɧɟɝɨɫɭɞɚɪɫɬɜɟɧɧɵɟ ɦɟɠɞɭɧɚɪɨɞɧɵɟ ɨɪɝɚɧɢɡɚɰɢɢ ɂ ɩɨɞɱɢɧɟɧɢɟ ɬɪɟɛɨɜɚɧɢɹɦ ɷɬɢɯ ɨɪɝɚɧɢɡɚɰɢɣ ɜɧɟɫɬɢ ɤɚɤɢɟ ɬɨ ɢɡɦɟɧɟɧɢɹ ɜ ɧɚɰɢɨɧɚɥɶɧɨɟ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɨ ɞɚɠɟ ɜɨɨɛɳɟ ɩɪɢɧɹɬɶ ɰɟɥɵɣ ɡɚɤɨɧ ɩɨɫɜɹɳɺɧɧɵɣ ɫɨɡɞɚɧɢɸ ɭɫɥɨɜɢɣ ɞɥɹ ɩɪɨɜɟɞɟɧɢɹ ɱɟɦɩɢɨɧɚɬɚ ɩɨ ɮɭɬɛɨɥɭ ɟɫɥɢ ɦɵ ɢɝɧɨɪɢɪɭɟɦ ɩɪɢɨɪɢɬɟɬɧɨɟ ɡɧɚɱɟɧɢɟ OH[ VSRUWLYD ɞɨɥɠɧɨ ɛɵɥɨ ɛɵ ɪɚɫɰɟɧɢɜɚɬɶɫɹ ɤɚɤ ɝɪɭɛɨɟ ɩɨɫɹɝɚɬɟɥɶɫɬɜɨ ɧɚ ɩɭɛɥɢɱɧɵɣ ɩɨɪɹɞɨɤ ɜ ɝɨɫɭɞɚɪɫɬɜɟ ɨɞɧɚɤɨ ɠɟ ɨɛɨɫɧɨɜɚɧɧɨ ɧɟ ɪɚɫɰɟɧɢɜɚɟɬɫɹ
ɜ ɫɨɪɟɜɧɨɜɚɧɢɹɯ ɩɨ ɛɨɤɫɭ ɤɚɪɚɬɟ ɢ ɢɧɵɦ ɫɩɨɪɬɢɜɧɵɦ ɟɞɢɧɨɛɨɪɫɬɜɚɦ ɫɚɦ ɮɚɤɬ ɧɚɧɟɫɟɧɢɹ ɩɨɛɨɟɜ ɢ ɤɚɤ ɫɥɟɞɫɬɜɢɟ ɧɚɧɟɫɟɧɢɹ ɜɪɟɞɚ ɡɞɨɪɨɜɶɸ ɨɰɟɧɢɜɚɟɬɫɹ ɧɟ ɫ ɩɨɡɢɰɢɢ ɧɨɪɦ ɭɝɨɥɨɜɧɨɝɨ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɚ ɤɚɤ ɷɬɨ ɛɵɥɨ ɛɵ ɜ ɥɸɛɨɣ ɢɧɨɣ ɫɢɬɭɚɰɢɢ ɜɧɟ ɪɚɦɨɤ ɫɩɨɪɬɢɜɧɵɯ ɫɨɪɟɜɧɨɜɚɧɢɣ ɚ ɜ ɪɚɦɤɚɯ ɢɦɟɧɧɨ OH[ VSRUWLYD ± ɩɪɚɜɢɥ ɩɪɨɜɟɞɟɧɢɹ ɬɚɤɢɯ ɫɨɪɟɜɧɨɜɚɧɢɣ Ɍɨ ɟɫɬɶ ɬɚɤɢɟ ɫɢɬɭɚɰɢɢ ɜɵɜɨɞɹɬɫɹ ɢɡ ɩɨɞ ɞɟɣɫɬɜɢɹ ɭɝɨɥɨɜɧɨɝɨ ɡɚɤɨɧɚ ɱɬɨ ɧɢɝɞɟ ɧɚɩɪɹɦɭɸ ɡɚɤɨɧɨɞɚɬɟɥɶɧɨ ɧɟ ɡɚɤɪɟɩɥɟɧɨ ɧɨ ɩɨ ɭɦɨɥɱɚɧɢɸ ɩɪɢɡɧɚɺɬɫɹ ɝɨɫɭɞɚɪɫɬɜɨɦ
ɜ ɰɟɥɨɦ ɥɸɛɨɟ ɧɚɧɟɫɟɧɢɟ ɜɪɟɞɚ ɡɞɨɪɨɜɶɸ ɫɩɨɪɬɫɦɟɧɚ ɜɨ ɜɪɟɦɹ
ɫɩɨɪɬɢɜɧɵɯ ɬɪɟɧɢɪɨɜɨɤ ɢ ɫɩɨɪɬɢɜɧɵɯ ɫɨɪɟɜɧɨɜɚɧɢɣ ɜɨ ɜɪɟɦɹ ɯɨɤɤɟɣɧɨɝɨ ɛɟɣɫɛɨɥɶɧɨɝɨ ɢɥɢ ɮɭɬɛɨɥɶɧɨɝɨ ɦɚɬɱɚ ɜɨ ɜɪɟɦɹ ɜɵɫɬɭɩɥɟɧɢɣ ɝɢɦɧɚɫɬɨɜ ɢ ɬ ɞ ɟɫɥɢ ɦɵ ɢɫɤɥɸɱɚɟɦ OH[ VSRUWLYD ɞɨɥɠɧɨ ɪɚɫɫɦɚɬɪɢɜɚɬɶɫɹ ɥɢɛɨ ɤɚɤ ɭɝɨɥɨɜɧɨɟ ɩɪɟɫɬɭɩɥɟɧɢɟ ɥɢɛɨ ɤɚɤ ɩɪɨɢɡɜɨɞɫɬɜɟɧɧɚɹ ɬɪɚɜɦɚ ɧɨ ɧɟ ɪɚɫɫɦɚɬɪɢɜɚɟɬɫɹ ɇɟɜɨɡɦɨɠɧɨ ɫɜɟɫɬɢ ɜɪɟɞ ɡɞɨɪɨɜɶɸ ɫɩɨɪɬɫɦɟɧɚɦ ɜɨ ɜɪɟɦɹ ɫɩɨɪɬɢɜɧɵɯ ɫɨɫɬɹɡɚɧɢɣ ɢɥɢ ɬɪɟɧɢɪɨɜɨɤ ɢɫɤɥɸɱɢɬɟɥɶɧɨ ɤ ɢɯ ©ɫɚɦɨɞɟɹɬɟɥɶɧɨɫɬɢªɩɨɞɫɜɨɣɫɬɪɚɯɢɪɢɫɤɩɨɫɤɨɥɶɤɭɫɩɟɰɢɮɢɤɚɫɩɨɪɬɚ ɬɚɤɨɜɚ ɱɬɨ ɪɢɫɤ ɭɤɚɡɚɧɧɨɝɨ ɜɪɟɞɚ ɨɛɴɟɤɬɢɜɧɨ ɫɭɳɟɫɬɜɭɟɬ ɢ ɢɦɟɟɬ ɬɟɧɞɟɧɰɢɸ ɭɜɟɥɢɱɢɜɚɬɶɫɹ ɦɭɥɶɬɢɩɥɢɰɢɪɨɜɚɬɶɫɹ ɢ ɭɫɥɨɠɧɹɬɶɫɹ ɩɨ ɦɟɪɟ ɪɚɡɜɢɬɢɹ ɫɩɨɪɬɚ
ɫɩɟɰɢɮɢɱɟɫɤɢɟ ɧɚɤɚɡɚɧɢɹ ɜ ɫɩɨɪɬɟ ɩɪɨɢɫɬɟɤɚɸɳɢɟ ɢɡ OH[ VSRUWLYD ɫ ɬɨɱɤɢ ɡɪɟɧɢɹ ɩɭɛɥɢɱɧɨɝɨ ɩɪɚɜɚ ɬɨ ɟɫɬɶ ɫɚɧɤɰɢɨɧɢɪɨɜɚɧɧɨɝɨ ɝɨɫɭɞɚɪɫɬɜɨɦ Ɂɚɤɨɧɚ ɫɨɜɟɪɲɟɧɧɨ ɧɟɥɨɝɢɱɧɵ ɢ ɧɟɤɨɪɪɟɤɬɧɵ ȿɫɥɢ ɦɵ ɢɝɧɨɪɢɪɭɟɦ ɩɪɢɨɪɢɬɟɬɧɨɟ ɡɧɚɱɟɧɢɟ OH[ VSRUWLYD ɩɨ ɨɩɪɟɞɟɥɺɧɧɨɦɭ ɤɪɭɝɭ ɨɬɧɨɲɟɧɢɣ ɬɨ ɤ ɩɪɢɦɟɪɭ ɞɢɫɤɜɚɥɢɮɢɤɚɰɢɹ ɫɩɨɪɬɫɦɟɧɚ ɤɚɤ ɦɟɪɚ ɞɢɫɰɢɩɥɢɧɚɪɧɨɣ ɨɬɜɟɬɫɬɜɟɧɧɨɫɬɢ ɩɨɥɨɠɢɦ ɡɚ ɩɪɨɹɜɥɟɧɢɟ ɧɚɫɢɥɢɹ ɜ ɨɬɧɨɲɟɧɢɢ ɫɨɩɟɪɧɢɤɚ ɞɨɥɠɧɚ ɤɜɚɥɢɮɢɰɢɪɨɜɚɬɶɫɹ ɤɚɤ ɝɪɭɛɟɣɲɟɟ ɩɨɫɹɝɚɬɟɥɶɫɬɜɨ ɧɚ ɟɝɨ ɤɨɧɫɬɢɬɭɰɢɨɧɧɵɟ ɩɪɚɜɚ ɧɚ ɡɚɧɹɬɢɟ ɫɩɨɪɬɨɦ ɧɚ ɬɪɭɞ ɢ ɬ ɞ ɢ ɧɚɩɪɨɬɢɜ ɜɨɡɧɢɤɚɟɬ ɜɨɩɪɨɫ ɧɚ ɤɚɤɨɦ ɨɫɧɨɜɚɧɢɢ ɫɩɨɪɬɫɦɟɧ ɜɵɜɟɞɟɧ ɜ ɞɚɧɧɨɣ ɫɢɬɭɚɰɢɢ ɢɡ ɩɨɞ ɞɟɣɫɬɜɢɹ ɫɚɧɤɰɢɣ ɭɝɨɥɨɜɧɨɝɨ ɢɥɢ ɚɞɦɢɧɢɫɬɪɚɬɢɜɧɨɝɨ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɚ
ɭɫɬɚɧɨɜɥɟɧɢɟ ɢɫɤɥɸɱɢɬɟɥɶɧɵɯ ɩɪɚɜ ɧɚ ɜɟɳɚɧɢɟ ɫɩɨɪɬɢɜɧɵɯ ɫɨɪɟɜɧɨɜɚɧɢɣ ɜɧɟ ɩɨɧɢɦɚɧɢɹ ɡɧɚɱɟɧɢɹ OH[ VSRUWLYD ɧɟ ɧɚɯɨɞɢɬ ɨɛɴɹɫɧɟɧɢɣ
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
ɩɨɫɤɨɥɶɤɭ ɜ ɬɚɤɨɦ ɫɥɭɱɚɟ ɞɨɥɠɧɨ ɛɵɥɨ ɛɵ ɩɪɢɡɧɚɜɚɬɶɫɹ ɤɚɤ ɩɨɫɹɝɚɸɳɟɟ ɧɚ ɫɜɨɛɨɞɭ ɢɧɮɨɪɦɚɰɢɢ ɢ ɧɟ ɭɤɥɚɞɵɜɚɥɨɫɶ ɛɵ ɞɨғɥɠɧɵɦ ɤɨɪɪɟɤɬɧɵɦ ɨɛɪɚɡɨɦ ɜ ɫɬɪɨɣɧɭɸ ɫɢɫɬɟɦɭ ɚɜɬɨɪɫɤɨɝɨ ɩɪɚɜɚ
ɫɩɨɪɬɢɜɧɵɣ ɤɨɧɬɪɚɤɬ ɜ Ɍɪɭɞɨɜɨɦ ɤɨɞɟɤɫɟ Ɋɨɫɫɢɣɫɤɨɣ Ɏɟɞɟɪɚɰɢɢ ɝɥɚɜɚ ± ɷɬɨ ɮɚɤɬ ɭɠɟ ɫɨɫɬɨɹɜɲɟɣɫɹ ɢɦɩɥɟɦɟɧɬɚɰɢɢ OH[ VSRUWLYD ɜ ɪɨɫɫɢɣɫɤɨɟ ɧɚɰɢɨɧɚɥɶɧɨɟ ɩɪɚɜɨ
ɉɪɢɦɟɪɨɜ ɦɨɠɧɨ ɩɪɢɜɟɫɬɢ ɟɳɺ ɧɟɦɚɥɨ
ɇɟɫɥɭɱɚɣɧɨ ɩɭɧɤɬ ɫɬɚɬɶɢ Ɏɟɞɟɪɚɥɶɧɨɝɨ ɡɚɤɨɧɚ ©Ɉ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɟ ɢ ɫɩɨɪɬɟ ɜ Ɋɨɫɫɢɣɫɤɨɣ Ɏɟɞɟɪɚɰɢɢª ɨɬ ʋ ɎɁ ɪɟɞ ɨɬ ɜ ɤɚɱɟɫɬɜɟ ɨɞɧɨɝɨ ɢɡ ɨɫɧɨɜɧɵɯ ɩɪɢɧɰɢɩɨɜ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɚ Ɋɨɫɫɢɣɫɤɨɣ Ɏɟɞɟɪɚɰɢɢ ɨ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɟ ɢ ɫɩɨɪɬɟ ɭɫɬɚɧɚɜɥɢɜɚɟɬ ɩɪɢɧɰɢɩ ©ɫɨɱɟɬɚɧɢɹ ɝɨɫɭɞɚɪɫɬɜɟɧɧɨɝɨ ɪɟɝɭɥɢɪɨɜɚɧɢɹ
ɨɬɧɨɲɟɧɢɣ ɜ ɨɛɥɚɫɬɢ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɵ ɢ ɫɩɨɪɬɚ ɫ ɫɚɦɨɪɟɝɭɥɢɪɨɜɚɧɢɟɦ ɬɚɤɢɯ ɨɬɧɨɲɟɧɢɣ ɫɭɛɴɟɤɬɚɦɢ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɵ ɢ ɫɩɨɪɬɚª
ȼɵɲɟɩɪɢɜɟɞɺɧɧɵɟ ɩɪɢɦɟɪɵ ɩɪɟɫɥɟɞɨɜɚɥɢ ɨɞɧɭ ɰɟɥɶ ± ɩɨɤɚɡɚɬɶ ɱɬɨ ɢɝɧɨɪɢɪɨɜɚɧɢɟ ɢɥɢ ɨɬɪɢɰɚɧɢɟ ɲɢɪɨɤɨ ɪɚɫɩɪɨɫɬɪɚɧɢɜɲɟɣɫɹ ɫɟɝɨɞɧɹ ɩɪɚɤɬɢɤɢ ɜɡɚɢɦɨɩɪɨɧɢɤɧɨɜɟɧɢɹ ɫɩɨɪɬɢɜɧɨɝɨ ɩɪɚɜɚ ɢ OH[ VSRUWLYD ɧɟ ɬɨɥɶɤɨ ɭɠɟ ɥɢɲɟɧɨ ɫɦɵɫɥɚ ɩɨɫɤɨɥɶɤɭ ɬɚɤɨɜɨɟ ɟɫɬɶ ɩɨɜɫɟɞɧɟɜɧɨɫɬɶ ɭɱɢɬɵɜɚɹ ɦɚɫɲɬɚɛɵ ɩɪɨɧɢɡɚɧɧɨɫɬɢ ɢɧɬɟɪɟɫɨɦ ɤ ɫɩɨɪɬɭ ɫɨɜɪɟɦɟɧɧɨɣ ɨɛɳɟɫɬɜɟɧɧɨɣ ɠɢɡɧɢ ɧɨ ɢ ɜɵɫɬɭɩɚɟɬ ɮɚɤɬɨɪɨɦ ɜɨɫɩɪɟɩɹɬɫɬɜɨɜɚɧɢɹ ɧɨɪɦɚɥɶɧɨɦɭ ɪɚɡɜɢɬɢɸ ɫɮɟɪɵ ɫɩɨɪɬɚ
Ɉɫɨɛɟɧɧɨɫɬɢ ɢɧɬɟɪɪɟɥɹɰɢɢ OH[ VSRUWLYD ɢ OH[ PHUFDWRULD
Ʉɚɤ ɩɢɲɟɬ Ɇɚɪɤɭɫ Ɇɚɡɭɤɤɨ ©ɝɥɨɛɚɥɢɡɚɰɢɹ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɫɭɳɟɫɬɜɟɧɧɵɦ ɨɛɪɚɡɨɦ ɫɦɟɫɬɢɥɚ ɧɨɪɦɚɬɢɜɧɨɟ ɪɟɝɭɥɢɪɨɜɚɧɢɟ ɦɟɠɞɭɧɚɪɨɞɧɨɣ ɫɩɨɪɬɢɜɧɨɣ ɫɢɫɬɟɦɵ ɜ ɨɛɥɚɫɬɶ ɱɚɫɬɧɵɯ ɩɨɥɧɨɦɨɱɢɣ ɦɟɠɞɭɧɚɪɨɞɧɵɯ ɢ ɧɚɰɢɨɧɚɥɶɧɵɯ ɫɩɨɪɬɢɜɧɵɯ ɨɪɝɚɧɢɡɚɰɢɣ Ɍɚɤɨɟ ɜɨɡɪɚɫɬɚɧɢɟ ɪɨɥɢ ɫɚɦɨɭɩɪɚɜɥɟɧɢɹ ɜ ɫɩɨɪɬɟ ɩɪɢɜɟɥɨ ɤ ɪɚɡɜɢɬɢɸ OH[ VSRUWLYD ɮɭɧɤɰɢɨɧɢɪɭɸɳɟɝɨ ɧɟɡɚɜɢɫɢɦɨ ɢ ɚɜɬɨɧɨɦɧɨ ɨɬ ɧɚɰɢɨɧɚɥɶɧɵɯ ɩɪɚɜɨɜɵɯ ɫɢɫɬɟɦ ɋ ɷɬɨɣ ɬɨɱɤɢ ɡɪɟɧɢɹ ɪɚɡɜɢɬɢɟ ɜɧɟɩɪɚɜɨɜɨɝɨ ɪɟɝɭɥɢɪɨɜɚɧɢɹ ɫɩɨɪɬɚ ɪɚɫɫɦɚɬɪɢɜɚɟɬɫɹ ɤɚɤ ɩɪɨɞɜɢɠɟɧɢɟ ɤ ɬɪɚɧɫɧɚɰɢɨɧɚɥɢɡɚɰɢɢ ɧɨɪɦɚɬɢɜɧɨɣ ɫɢɫɬɟɦɵ ɚɧɚɥɨɝɢɱɧɨ ɢɧɵɦ ɮɨɪɦɚɦ ɭɧɢɜɟɪɫɚɥɶɧɨɝɨ ɩɪɚɜɚ ɬɚɤɢɦ ɤɚɤ OH[ PHUFDWRULD ɤɨɬɨɪɵɣ ɦɨɠɧɨ ɪɚɫɫɦɚɬɪɢɜɚɬɶ ɤɚɤ ³ɩɚɪɚɞɢɝɦɚɥɶɧɵɣ´ ɩɪɢɦɟɪ ɬɪɚɧɫɧɚɰɢɨɧɚɥɶɧɨɝɨ ɚɜɬɨɧɨɦɧɨɝɨ ɧɨɪɦɚɬɢɜɧɨɝɨ ɩɨɪɹɞɤɚª
Mazzucco M.F. /H[ VSRUWLYD 6SRUWV ODZ DV D WUDQVQDWLRQDO DXWRQRPRXV OHJDO RUGHU 7KHVLV >/H[ VSRUWLYD ɋɩɨɪɬɢɜɧɵɣ ɡɚɤɨɧ ɤɚɤ ɬɪɚɧɫɧɚɰɢɨɧɚɥɶɧɵɣ ɚɜɬɨɧɨɦɧɵɣ ɧɨɪɦɚɬɢɜɧɵɣ ɩɨɪɹɞɨɤ Ⱦɢɫ ɞɨɤɬɨɪɚ ɩɪɚɜɚ@ 8QLYHUVLW\ RI 9LFWRULD ± 9LFWRULD %ULWLVK &ROXPELD &DQDGD ± S ± 3
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
Ɏɪɟɞɟɪɢɤ Ȼɸɣ ɀɚɧ Ɇɢɲɟɥɶ Ɇɚɪɦɷɣɭ Ⱦɢɞɶɟ ɉɨɪɚɤɤɶɹ ɢ Ɏɚɛɪɢɫ Ɋɢɰɰɨ ɨɬɦɟɱɚɸɬ ɱɬɨ OH[ VSRUWLYD ɩɨɫɬɪɨɟɧ ɩɨ ɚɧɚɥɨɝɢɢ ɫ ɦɨɞɟɥɶɸ OH[ PHUFDWRULD ©ɛɵɥ ɩɨɫɬɪɨɟɧ ɢ ɮɭɧɤɰɢɨɧɢɪɭɟɬ ɜ ɫɩɨɪɬɢɜɧɨɦ ɦɢɪɟ ɱɬɨɛɵ ɪɟɚɥɢɡɨɜɵɜɚɬɶ ɬɟ ɠɟ ɢɧɬɟɪɟɫɵ ɱɬɨ ɢ ɭ OH[ PHUFDWRULDª
/H[ PHUFDWRULD ± ɷɬɨ ɫɨɜɨɤɭɩɧɨɫɬɶ ɩɪɚɜɢɥ ɩɨɜɟɞɟɧɢɹ ɜɵɪɚɛɨɬɚɧɧɵɯ ɭɱɚɫɬɧɢɤɚɦɢ ɦɟɠɞɭɧɚɪɨɞɧɨɝɨ ɤɨɦɦɟɪɱɟɫɤɨɝɨ ɨɛɨɪɨɬɚ ɜ ɯɨɞɟ ɨɫɭɳɟɫɬɜɥɟɧɢɹ ɫɜɨɟɣ ɞɟɹɬɟɥɶɧɨɫɬɢ ɢ ɩɪɢɦɟɧɹɟɦɵɯ ɩɪɢ ɪɚɫɫɦɨɬɪɟɧɢɢ ɫɩɨɪɚ ɦɟɠɞɭɧɚɪɨɞɧɵɦ ɤɨɦɦɟɪɱɟɫɤɢɦ ɚɪɛɢɬɪɚɠɟɦ
ɋɨɝɥɚɫɧɨ Ⱦɢɦɢɬɪɢɨɫɭ ɉɚɧɚɝɢɨɬɨɩɭɥɨɫɭ OH[ PHUFDWRULD ɩɪɟɞɫɬɚɜɥɹɟɬ
ɫɨɛɨɣ ɫɚɦɨɩɪɨɢɡɜɨɥɶɧɨ ɫɨɡɞɚɜɚɟɦɵɣ ɨɩɪɟɞɟɥɺɧɧɵɣ ɧɚɛɨɪ ɧɨɪɦ ɨɛɵɱɧɨɝɨ ɩɪɚɜɚ ɢ ɨɫɧɨɜɧɵɯ ɨɛɳɢɯ ɩɪɢɧɰɢɩɨɜ ɤɨɬɨɪɵɟ ɫɨɫɬɚɜɥɹɸɬ ɚɜɬɨɧɨɦɧɭɸ ɧɨɪɦɚɬɢɜɧɭɸ ɫɢɫɬɟɦɭ ɢ ɨɫɭɳɟɫɬɜɥɹɸɬ ɨɫɧɨɜɧɨɟ ɪɟɝɭɥɢɪɨɜɚɧɢɟ ɦɟɠɞɭɧɚɪɨɞɧɵɯ ɬɨɪɝɨɜɵɯ ɢ ɤɨɦɦɟɪɱɟɫɤɢɯ ɨɬɧɨɲɟɧɢɣ ɛɟɡ ɫɜɹɡɢ ɫ ɤɚɤɨɣ ɥɢɛɨ ɧɚɰɢɨɧɚɥɶɧɨɣ ɩɪɚɜɨɜɨɣ ɫɢɫɬɟɦɨɣ /H[ VSRUWLYD ɨɬɦɟɱɚɟɬ Ⱦ ɉɚɧɚɝɢɨɬɨɩɭɥɨɫ ɜɨɡɧɢɤ ɩɨɱɬɢ ɬɚɤ ɠɟ ɤɚɤ ɢ OH[ PHUFDWRULD ɬɨ ɟɫɬɶ ɩɨɫɪɟɞɫɬɜɨɦ ɦɟɞɥɟɧɧɨɝɨ ɮɨɪɦɢɪɨɜɚɧɢɹ ɨɩɪɟɞɟɥɺɧɧɨɝɨ ɧɚɛɨɪɚ ɧɨɪɦ ɜ ɪɚɦɤɚɯ ɭɠɟ ɭɫɬɚɧɨɜɥɟɧɧɨɣ ɪɚɧɟɟ ɫɢɫɬɟɦɵ ɧɨɪɦ ɢ ɩɪɚɜɢɥ
ɉɨɞɨɛɧɨ OH[ PHUFDWRULD ɢɫɬɨɱɧɢɤ ɫɬɚɬɭɫɚ OH[ VSRUWLYD ɤɚɤ ɱɚɫɬɧɨɝɨ ɩɪɚɜɚ ɨɫɧɨɜɵɜɚɟɬɫɹ ɧɚ ɩɨɧɹɬɢɢ ɞɨɝɨɜɨɪɚ ɧɟ ɬɪɟɛɭɸɳɟɝɨ ɫɚɧɤɰɢɨɧɢɪɨɜɚɧɢɹ ɢɥɢ ɪɚɬɢɮɢɤɚɰɢɢ ɝɨɫɭɞɚɪɫɬɜɨɦ ɞɨɝɨɜɨɪɚ ɢɦɟɸɳɟɝɨ ɸɪɢɞɢɱɟɫɤɭɸ ɫɢɥɭ ɜ ɫɢɥɭ ɬɨɥɶɤɨ ɟɝɨ ɧɚɥɢɱɢɹ
ȼ Ɋɟɲɟɧɢɢ ɨɬ ʋ Ɇɟɠɞɭɧɚɪɨɞɧɵɣ ɫɩɨɪɬɢɜɧɵɣ ɚɪɛɢɬɪɚɠɧɵɣ ɫɭɞ ɜ ɝ Ʌɨɡɚɧɧɚ ɭɤɚɡɚɥ ɧɚ ɬɨ ɱɬɨ ɜ ɪɚɦɤɚɯ ɫɩɨɪɬɢɜɧɨɝɨ ɩɪɚɜɚ ɩɨɥɭɱɢɥ ɫɜɨɺ ɪɚɡɜɢɬɢɟ ɢ ɤɨɧɫɨɥɢɞɚɰɢɸ ɧɚ ɩɪɨɬɹɠɟɧɢɢ ɭɠɟ ɦɧɨɝɢɯ ɥɟɬ ɜ ɱɚɫɬɧɨɫɬɢ ɱɟɪɟɡ ɭɪɟɝɭɥɢɪɨɜɚɧɢɟ ɫɩɨɪɨɜ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜ ɚɪɛɢɬɪɚɠɧɵɯ ɢ ɬɪɟɬɟɣɫɤɢɯɫɭɞɚɯɧɚɛɨɪɧɟɩɢɫɚɧɵɯɩɪɚɜɨɜɵɯɩɪɢɧɰɢɩɨɜɫɜɨɟɝɨɪɨɞɚOH[ PHUFDWRULD ɞɥɹ ɫɩɨɪɬɚ ɢɥɢ ɤɚɤ ɟɝɨ ɟɳɺ ɧɚɡɵɜɚɸɬ OH[ OXGLFD ɤɨɬɨɪɨɦɭ ɧɚɰɢɨɧɚɥɶɧɵɟ ɢ ɦɟɠɞɭɧɚɪɨɞɧɵɟ ɫɩɨɪɬɢɜɧɵɟ ɮɟɞɟɪɚɰɢɢ ɞɨɥɠɧɵ
Buy F., Marmayou J.-M., Poracchia D., Rizzo F. 'URLWGX6SRUW0DQXHO>ɋɩɨɪɬɢɜɧɨɟ ɩɪɚɜɨ ɍɱ @ qPH pGLWLRQ ± 3DULV /LEUDLULH *pQpUDOH GH 'URLW HW GH -XULVSUXGHQFH ± S ± 3 ±
Ⱥɛɥɺɡɝɨɜɚ Ɉ.ȼ. ɇɨɪɦɵ ©OH[ PHUFDWRULDª ɜ ɩɪɚɜɨɜɨɦ ɪɟɝɭɥɢɪɨɜɚɧɢɢ ɦɟɠɞɭɧɚɪɨɞɧɨɝɨ ɤɨɦɦɟɪɱɟɫɤɨɝɨ ɨɛɨɪɨɬɚ Ⱥɜɬɨɪɟɮ ɞɢɫ ɤɚɧɞ ɸɪɢɞɢɱ ɧɚɭɤ Ɋɨɫɫɢɣɫɤɚɹ ɚɤɚɞɟɦɢɹ ɩɪɚɜɨɫɭɞɢɹ ± Ɇ ± ɋ
Panagiotopoulos D.P. /H[ 6SRUWLYD 7KHRU\ 3DUW >/H[ 6SRUWLYD Ɍɟɨɪɢɹ ɑɚɫɬɶ @ KWWS ZZZ VSRUWPHQHG]VPHQW KX GRNVL OH[VSRUWLYDBHQ GRF! ± S ± 3
Mazzucco M.F. /H[ VSRUWLYD 6SRUWV ODZ DV D WUDQVQDWLRQDO DXWRQRPRXV OHJDO RUGHU 7KHVLV >/H[ VSRUWLYD ɋɩɨɪɬɢɜɧɵɣ ɡɚɤɨɧ ɤɚɤ ɬɪɚɧɫɧɚɰɢɨɧɚɥɶɧɵɣ ɚɜɬɨɧɨɦɧɵɣ ɧɨɪɦɚɬɢɜɧɵɣ ɩɨɪɹɞɨɤ Ⱦɢɫ ɞɨɤɬɨɪɚ ɩɪɚɜɚ@ 8QLYHUVLW\ RI 9LFWRULD ± 9LFWRULD %ULWLVK &ROXPELD &DQDGD ± S ± 3
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
ɫɨɨɬɜɟɬɫɬɜɨɜɚɬɶ ɢ ɩɨɞɱɢɧɹɬɶɫɹ ɧɟɡɚɜɢɫɢɦɨ ɨɬ ɧɚɥɢɱɢɹ ɬɚɤɢɯ ɩɪɢɧɰɢɩɨɜ ɜ ɫɜɨɢɯ ɭɫɬɚɜɚɯ ɢɥɢ ɧɚɰɢɨɧɚɥɶɧɵɯ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɚɯ
Ʉɨɧɰɟɩɰɢɹ OH[ VSRUWLYD ɛɟɡɭɫɥɨɜɧɨ ɫɯɨɠɚ ɫ ɤɨɧɰɟɩɰɢɟɣ OH[ PHUFDWRULD
Ʉɚɤ ɨɬɦɟɱɚɟɬ Ʉɟɧ Ɏɨɫɬɟɪ OH[ PHUFDWRULD ɢɦɟɟɬ ɞɨɥɝɭɸ ɢɫɬɨɪɢɸ ɢ ɧɚ ɧɚɫɬɨɹɳɢɣ
ɦɨɦɟɧɬ ɧɟ ɫɭɳɟɫɬɜɭɟɬ ɭɧɢɜɟɪɫɚɥɶɧɨɝɨ ɩɨɥɧɨɫɬɶɸ ɫɨɝɥɚɫɨɜɚɧɧɨɝɨ ɦɧɟɧɢɹ ɩɨ ɩɨɜɨɞɭ ɬɨɝɨ ɱɬɨ ɤɨɧɤɪɟɬɧɨ ɜɯɨɞɢɬ ɜ ɩɨɧɹɬɢɟ OH[ PHUFDWRULD Ɍɟɦ ɧɟ ɦɟɧɟɟ ɜɨɡɦɨɠɧɨ ɜɵɞɟɥɢɬɶ ɤɥɸɱɟɜɵɯ ɷɥɟɦɟɧɬɚ ɧɨɪɦɵ OH[ PHUFDWRULD ɫɨɡɞɚɸɬɫɹ ɜɫɥɟɞɫɬɜɢɟ ɫɨɡɞɚɧɢɹ ɦɟɠɞɭɧɚɪɨɞɧɨɝɨ ɨɛɵɱɚɹ ɢ ɩɪɚɤɬɢɤɢ ɬɨɪɝɨɜɵɯ ɞɨɝɨɜɨɪɨɜ ɤɨɬɨɪɵɟ ɫɨ ɜɪɟɦɟɧɟɦ ɫɬɚɧɞɚɪɬɢɡɢɪɭɸɬɫɹ ɪɚɡɪɟɲɟɧɢɟ ɦɟɠɞɭɧɚɪɨɞɧɵɯ ɬɨɪɝɨɜɵɯ ɫɩɨɪɨɜ ɩɨɫɪɟɞɫɬɜɨɦ ɚɪɛɢɬɪɚɠɚ ɹɜɥɹɟɬɫɹ ɛɨɥɟɟ ɪɚɫɩɪɨɫɬɪɚɧɺɧɧɵɦ ɢ ɡɧɚɱɢɦɵɦ ɱɟɦ ɪɚɡɪɟɲɟɧɢɟ ɬɚɤɢɯ ɫɩɨɪɨɜ ɜ ɫɭɞɚɯ ɜ ɫɨɨɬɜɟɬɫɬɜɭɸɳɢɯ ɞɨɝɨɜɨɪɚɯ ɡɚɤɥɸɱɚɟɦɵɯ ɜ ɪɚɦɤɚɯ OH[ PHUFDWRULD ɦɨɝɭɬ ɫɨɞɟɪɠɚɬɶɫɹ ɩɨɥɨɠɟɧɢɹ ɨ ɧɟɞɨɩɭɫɬɢɦɨɫɬɢ ɩɪɢɦɟɧɟɧɢɹ ɧɨɪɦ ɧɚɰɢɨɧɚɥɶɧɨɝɨ ɡɚɤɨɧɨɞɚɬɟɥɶɫɬɜɚ ɗɬɢ ɬɪɢ ɷɥɟɦɟɧɬɚ OH[ PHUFDWRULD ɹɜɥɹɸɬɫɹ ɚɧɚɥɨɝɢɱɧɵɦɢ ɷɥɟɦɟɧɬɚɦ OH[ VSRUWLYD
/H[ VSRUWLYD ɢ OH[ PHUFDWRULD ɢɦɟɸɬ ɦɧɨɠɟɫɬɜɨ ɫɯɨɠɢɯ ɱɟɪɬ ɨɫɨɛɟɧɧɨ
ɜ ɢɯ ɩɪɨɢɫɯɨɠɞɟɧɢɢ ɜ ɰɟɥɨɦ ɢ ɜ ɨɫɨɛɟɧɧɨɫɬɢ ɜ ɢɯ ɪɚɡɜɢɬɢɢ ɚɪɛɢɬɪɚɠɧɵɦɢ ɫɭɞɚɦɢ
ɂ ɨɛɚ ɪɚɫɫɦɚɬɪɢɜɚɟɦɵɯ ɧɨɪɦɚɬɢɜɧɵɯ ɤɥɚɫɬɟɪɚ ɢɦɟɸɬ ɜɟɫɶɦɚ ɞɥɢɬɟɥɶɧɭɸ ɢɫɬɨɪɢɸ
Ɋ Ɇɚɤɥɚɪɟɧ ɨɬɦɟɱɚɥ ɱɬɨ ɫɭɳɟɫɬɜɭɸɬ ɪɚɡɧɵɟ ɜɡɝɥɹɞɵ ɧɚ ɫɨɨɬɧɨɲɟɧɢɟ OH[ VSRUWLYD ɢ OH[ PHUFDWRULD ɢ ɱɬɨ ɜɨɡɦɨɠɧɨ OH[ VSRUWLYD ɹɜɥɹɟɬɫɹ ɜɫɟɝɨ ɥɢɲɶ ɱɚɫɬɶɸ OH[ PHUFDWRULD ɧɨ ɜ ɥɸɛɨɦ ɫɥɭɱɚɟ ɚɧɚɥɨɝɢɹ ɦɟɠɞɭɧɢɦɢɧɚɥɢɰɨɌɚɤɠɟɤɚɤɢOH[PHUFDWRULDOH[VSRUWLYDɧɟɜɯɨɞɢɬɜ ɸɪɢɫɞɢɤɰɢɸ ɤɚɤɨɝɨ ɥɢɛɨ ɨɬɞɟɥɶɧɨɝɨ ɝɨɫɭɞɚɪɫɬɜɚ ɫɩɨɪɵ ɜ ɪɚɦɤɚɯ ɢ OH[ PHUFDWRULD ɢ OH[ VSRUWLYD ɪɚɡɪɟɲɚɸɬɫɹ ɩɨɫɪɟɞɫɬɜɨɦ ɚɪɛɢɬɪɚɠɚ ɩɪɢ ɷɬɨɦ ɫɬɨɪɨɧɵ ɬɚɤɢɯ ɫɩɨɪɨɜ ɦɨɝɭɬ ɛɵɬɶ ɢɡ ɚɛɫɨɥɸɬɧɨ ɪɚɡɧɵɯ ɪɟɝɢɨɧɨɜ Ɂɟɦɥɢ
ɍ ɧɨɪɦɚɬɢɜɧɵɯ ɭɫɬɚɧɨɜɥɟɧɢɣ OH[ VSRUWLYD ɢ OH[ PHUFDWRULD ɟɫɬɶ ɞɨɫɬɚɬɨɱɧɨ ɦɧɨɝɨ ɬɨɱɟɤ ɫɨɩɪɢɤɨɫɧɨɜɟɧɢɹ ɢ ɞɚɠɟ ɩɟɪɟɫɟɱɟɧɢɹ ɢ ɢɧɬɟɪɪɟɥɹɰɢɹ ɷɬɢɯ ɧɨɪɦ ɧɨɫɢɬ ɫɥɨɠɧɵɣ ɯɚɪɚɤɬɟɪ
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