Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
ɨɛɪɚɡɨɜɚɧɢɹ Ʉɨɪɨɥɟɜɫɤɢɣ ɍɤɚɡ ɨɬ ɭɫɬɚɧɨɜɢɥ ɞɥɹ ɨɛɳɢɯ ɢ ɬɟɯɧɢɱɟɫɤɢɯ ɜɵɫɲɢɯ ɭɱɟɛɧɵɯ ɡɚɜɟɞɟɧɢɣ ɨɛɹɡɚɬɟɥɶɧɵɟ ɡɚɧɹɬɢɹ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɨɣ ɜ ɨɛɴɺɦɟ ɧɟ ɦɟɧɟɟ ɞɜɭɯ ɱɚɫɨɜ ɜ ɧɟɞɟɥɸ ɞɥɹ ɜɫɟɯ ɤɭɪɫɨɜ Ʉɨɪɨɥɟɜɫɤɢɣ ɍɤɚɡ ɨɬ ɢ Ʉɨɪɨɥɟɜɫɤɢɣ Ⱦɟɤɪɟɬ ɨɬ ɭɫɬɚɧɨɜɢɥɢ ɬɪɟɛɨɜɚɧɢɹ ɤ ɮɢɡɤɭɥɶɬɭɪɧɨɦɭ ɜɨɫɩɢɬɚɧɢɸ ɭɱɚɳɢɯɫɹ ɫɪɟɞɧɢɯ ɲɤɨɥ Ʉɨɪɨɥɟɜɫɤɢɣ ɍɤɚɡ ɨɬ ɜɜɺɥ ɮɟɯɬɨɜɚɧɢɟ ɜ ɨɛɪɚɡɨɜɚɬɟɥɶɧɭɸ ɩɪɨɝɪɚɦɦɭ Ɇɚɞɪɢɞɫɤɨɝɨ ɢɧɫɬɢɬɭɬɚ ɉɟɪɜɵɣ ɜ ɂɫɩɚɧɢɢ ɨɛɳɟɝɨɫɭɞɚɪɫɬɜɟɧɧɵɣ ɩɨɥɧɨɰɟɧɧɵɣ ɢ ɩɪɨɮɢɥɶɧɵɣ Ɂɚɤɨɧ ɨ ɫɩɨɪɬɟ ɛɵɥ ɩɪɢɧɹɬ ɫɪɚɜɧɢɬɟɥɶɧɨ ɧɟɞɚɜɧɨ ± ɜ ɝɨɞɭ ɗɬɨ ɛɵɥ Ɂɚɤɨɧ ɂɫɩɚɧɢɢ ɨ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɟ ɨɬ ʋ
ɂɬɚɥɢɹ ȼ ɝɨɞɭ Ʉɨɪɨɥɟɜɫɤɢɦ ɭɤɚɡɨɦ ɨɬ ɛɵɥ ɭɱɪɟɠɞɺɧ ɜ ɤɚɱɟɫɬɜɟ ɸɪɢɞɢɱɟɫɤɨɝɨ ɥɢɰɚ ɫɩɨɪɬɢɜɧɵɣ ɤɥɭɛ ©Ʌɚɰɢɨª Ʉɨɪɨɥɟɜɫɤɢɣ Ⱦɟɤɪɟɬ Ɂɚɤɨɧ ɨɬ ʋ ɢ ɢɡɦɟɧɢɜɲɢɣ ɟɝɨ Ɂɚɤɨɧ ɂɬɚɥɢɢ ɨɬ ʋ ɤɚɫɚɥɢɫɶ ɧɟɤɨɬɨɪɵɯ ɜɨɩɪɨɫɨɜ ɩɪɨɜɟɞɟɧɢɹ ɩɭɛɥɢɱɧɵɯɫɩɨɪɬɢɜɧɵɯɦɟɪɨɩɪɢɹɬɢɣɁɚɤɨɧɂɬɚɥɢɢɨɬʋ ɭɪɟɝɭɥɢɪɨɜɚɥ ɫɬɪɨɢɬɟɥɶɫɬɜɨ ɫɩɨɪɬɢɜɧɵɯ ɨɛɴɟɤɬɨɜ Ʉɨɪɨɥɟɜɫɤɢɣ ɞɟɤɪɟɬ ɨɬ ʋ ɭɱɪɟɞɢɥ ɤɚɤ ɸɪɢɞɢɱɟɫɤɨɟ ɥɢɰɨ Ƚɨɫɭɞɚɪɫɬɜɟɧɧɵɣ Ɏɨɧɞ ɫɬɪɚɯɨɜɚɧɢɹ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɇɨ ɩɟɪɜɵɦ ɤɪɭɩɧɵɦ ɩɪɨɮɢɥɶɧɵɦ ɧɨɪɦɚɬɢɜɧɵɦ ɩɪɚɜɨɜɵɦ ɚɤɬɨɦ ɂɬɚɥɢɢ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜɫɺ ɠɟ ɩɪɢɧɹɬɨ ɫɱɢɬɚɬɶ Ɂɚɤɨɧ ɂɬɚɥɢɢ ɨɬ ʋ ©ɍɫɬɚɜ ɢ ɪɟɝɥɚɦɟɧɬ ɇɚɰɢɨɧɚɥɶɧɨɝɨ ɨɥɢɦɩɢɣɫɤɨɝɨ ɤɨɦɢɬɟɬɚ ɂɬɚɥɢɢ &21, ª ɭɱɪɟɞɢɜɲɢɣ ɬɨɱɧɟɟ ± ɪɟɭɱɪɟɞɢɜɲɢɣ ɇɚɰɢɨɧɚɥɶɧɵɣ ɨɥɢɦɩɢɣɫɤɢɣ ɤɨɦɢɬɟɬ ɂɬɚɥɢɢ ɩɨɞ ɤɨɧɬɪɨɥɟɦ Ɇɢɧɢɫɬɟɪɫɬɜɚ ɬɭɪɢɡɦɚ ɢ ɪɚɡɜɥɟɱɟɧɢɣ ɂɬɚɥɢɢ
Ʉɚɧɚɞɚȼ ɝɨɞɭ ɛɵɥ ɩɪɢɧɹɬ Ɂɚɤɨɧ ɩɪɨɜɢɧɰɢɢ Ʉɜɟɛɟɤ ©Ɉ ɤɥɭɛɚɯ ɨɬɞɵɯɚª ɜ ɝɨɞɭ ɨɧ ɩɪɟɬɟɪɩɟɥ ɫɭɳɟɫɬɜɟɧɧɵɟ ɢɡɦɟɧɟɧɢɹ ȼ ɝɨɞɭ ɛɵɥ ɩɪɢɧɹɬ Ɂɚɤɨɧ ɩɪɨɜɢɧɰɢɢ Ʉɜɟɛɟɤ ɨ ɫɨɡɞɚɧɢɢ ɫɩɨɪɬɢɜɧɵɯ ɤɨɦɢɫɫɢɣ ɨɬɜɟɬɫɬɜɟɧɧɵɯ ɡɚ ɪɟɝɭɥɢɪɨɜɚɧɢɟ ɛɨɤɫɚ ɢ ɛɨɪɶɛɵ ȼ ɝɨɞɭ ɛɵɥ ɩɪɢɧɹɬ Ɂɚɤɨɧ ɩɪɨɜɢɧɰɢɢ Ʉɜɟɛɟɤ ©Ɉ ɩɪɨɜɢɧɰɢɚɥɶɧɨɦ ɫɨɜɟɬɟ ɩɨ ɫɩɨɪɬɭª ȼ ɝɨɞɭ ɛɵɥ ɩɪɢɧɹɬ Ɂɚɤɨɧ Ʉɚɧɚɞɵ ɨɬ ©Ɉ ɧɚɰɢɨɧɚɥɶɧɨɣ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɟª
Baena Extremera A. 5HSDVR KLVWyULFR GH OD OHJLVODFLyQ HGXFDWLYD HQ HGXFDFLyQ ItVLFD HVFRODU >ɂɫɬɨɪɢɱɟɫɤɢɣ ɨɛɡɨɪ ɩɪɚɜɨɜɨɝɨ ɪɟɝɭɥɢɪɨɜɚɧɢɹ ɲɤɨɥɶɧɨɝɨ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɜɨɫɩɢɬɚɧɢɹ@ KWWS GLJLWXP XP HV [POXL ELWVWUHDP 5HSDVR +LVW & % ULFR () SGI! López Fernández I. (YROXFLyQ KLVWyULFD GH OD IRUPDFLyQ LQLFLDO GHO SURIHVRUDGR GH HGXFDFLyQ ItVLFD HQ (VSDxD >ɂɫɬɨɪɢɱɟɫɤɨɟ ɪɚɡɜɢɬɢɟ ɧɚɱɚɥɶɧɨɣ ɩɨɞɝɨɬɨɜɤɢ ɭɱɢɬɟɥɟɣ ɩɨ ɮɢɡɢɱɟɫɤɨɦɭ ɜɨɫɩɢɬɚɧɢɸ ɜ ɂɫɩɚɧɢɢ@ KWWS KXHVSHGHV FLFD HV DOLHQV UHYIXHQWHV QXP FDPSRBDELHUWRB KWP!
Ʉɚɡɚɤɨɜ Ɋ.ȼ.Ɂɚɤɨɧɨɞɚɬɟɥɶɫɬɜɨ ɨ ɫɩɨɪɬɟ ɢ ɫɢɫɬɟɦɚ ɝɨɫɭɞɚɪɫɬɜɟɧɧɨɝɨ ɭɩɪɚɜɥɟɧɢɹ ɜ ɨɛɥɚɫɬɢ ɫɩɨɪɬɚ ɜ Ʉɚɧɚɞɟ Ʉɨɦɢɫ ɩɨ ɫɩɨɪɬ ɩɪɚɜɭ Ⱥɫɫɨɰ ɸɪɢɫɬɨɜ Ɋɨɫɫɢɢ ɇɚɰ ɨɛɴɟɞɢɧɟɧɢɟ ɫɩɨɪɬ ɸɪɢɫɬɨɜ ɊɎ ± Ɇ ± ɫ ± ɋ
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
Ʉɨɥɭɦɛɢɹ ɉɟɪɜɵɦ ɩɪɚɜɨɜɵɦ ɚɤɬɨɦ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜ Ʉɨɥɭɦɛɢɢ ɩɪɢɧɹɬɨ ɫɱɢɬɚɬɶ Ⱦɟɤɪɟɬ ɢɡɞɚɧɧɵɣ ɜ ɝɨɞɭ ɫɨɜɦɟɫɬɧɨ ɝɟɧɟɪɚɥɚɦɢ ɋɢɦɨɧɨɦ Ȼɨɥɢɜɚɪɨɦ ɢ Ɏɪɚɧɫɢɫɤɨ ɞɟ ɉɚɭɥɚ ɋɚɧɬɚɧɞɟɪɨɦ ɨ ɧɪɚɜɫɬɜɟɧɧɵɯ ɬɪɟɛɨɜɚɧɢɹɯ ɤ ɨɪɝɚɧɢɡɚɰɢɢ ɨɛɪɚɡɨɜɚɧɢɹ ɍɤɚɡ ɩɨɞɱɟɪɤɧɭɥ ɜɚɠɧɨɫɬɶ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɞɟɬɟɣ ɉɨɱɬɢ ɞɟɫɹɬɶ ɥɟɬ ɫɩɭɫɬɹ ɉɪɟɡɢɞɟɧɬ ȼɟɥɢɤɨɣɄɨɥɭɦɛɢɢɝɟɧɟɪɚɥɋɢɦɨɧȻɨɥɢɜɚɪɜȾɟɤɪɟɬɟɨɬʋ ɩɨɡɠɟɢɡɦɟɧɺɧɧɨɦȾɟɤɪɟɬɨɦɨɬ ɝɨɞɚɭɩɨɥɧɨɦɨɱɢɥɭɧɢɜɟɪɫɢɬɟɬɵɢ ɤɨɥɥɟɞɠɢ ɭɪɟɝɭɥɢɪɨɜɚɬɶ ɩɪɚɤɬɢɤɭ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɫɬɭɞɟɧɬɨɜ ȼɩɨɫɥɟɞɫɬɜɢɢ Ⱦɟɤɪɟɬ Ɂɚɤɨɧ Ʉɨɥɭɦɛɢɢ ɨɬ ɝɨɞɚ ʋ ɛɨɥɟɟ ɞɟɬɚɥɶɧɨ ɭɪɟɝɭɥɢɪɨɜɚɥ ɜɨɩɪɨɫɵ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɜ Ʉɨɥɭɦɛɢɢ ɉɨɫɬɚɧɨɜɥɟɧɢɟ ɉɪɚɜɢɬɟɥɶɫɬɜɚ Ʉɨɥɭɦɛɢɢ ɨɬ ʋ ɜɩɟɪɜɵɟ ɭɱɪɟɞɢɥɨ ɫɩɨɪɬɢɜɧɵɟ ɷɤɡɚɦɟɧɵ ɞɥɹ ɝɨɫɫɥɭɠɚɳɢɯ ɉɟɪɜɵɣ Ɂɚɤɨɧ ɨ ɮɢɡɢɱɟɫɤɨɣ ɤɭɥɶɬɭɪɟ Ɂɚɤɨɧ ʋ ɛɵɥ ɩɪɢɧɹɬ ɜ Ʉɨɥɭɦɛɢɢ ɜ ɝɨɞɭ Ⱦɟɤɪɟɬ ɨɬ ɝɨɞɚ ʋ ɭɫɬɚɧɨɜɢɥ ɨɛɹɡɚɬɟɥɶɧɨɫɬɶ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɜɨ ɜɫɟɯ ɨɛɪɚɡɨɜɚɬɟɥɶɧɵɯ ɭɱɪɟɠɞɟɧɢɹɯ ɧɚɱɚɥɶɧɨɝɨ ɫɪɟɞɧɟɝɨ ɢ ɜɵɫɲɟɝɨ ɨɛɪɚɡɨɜɚɧɢɹ
Ʉɭɛɚ Ⱦɟɤɪɟɬɨɦ ɨɬ ʋ ɛɵɥɨ ɭɱɪɟɠɞɟɧɨ Ƚɥɚɜɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɫɩɨɪɬɚ ȼ ɝɨɞɭ Ɂɚɤɨɧɨɦ Ⱦɟɤɪɟɬɨɦ ɨɬ ʋ ɭɤɚɡɚɧɧɵɣ ɨɪɝɚɧ ɛɵɥ ɩɪɟɨɛɪɚɡɨɜɚɧ ɜ ɇɚɰɢɨɧɚɥɶɧɭɸ ɤɨɦɢɫɫɢɸ ɩɨ ɫɩɨɪɬɭ Ⱦɟɤɪɟɬɨɦ ɨɬ ʋ ɛɵɥɢ ɭɫɬɚɧɨɜɥɟɧɵ ɞɨɩɨɥɧɢɬɟɥɶɧɵɟ ɩɨɥɨɠɟɧɢɹ ɨ ɇɚɰɢɨɧɚɥɶɧɨɣ ɤɨɦɢɫɫɢɢ ɩɨ ɫɩɨɪɬɭ
ɋɒȺȼ ɲɬɚɬɟ Ɍɟɯɚɫ ɨɞɧɢɦ ɢɡ ɩɟɪɜɵɯ ɧɨɪɦɚɬɢɜɧɵɯ ɩɪɚɜɨɜɵɯ ɚɤɬɨɜ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɹɜɢɥɚɫɶ ɢɡɞɚɧɧɚɹ ɢɫɩɚɧɫɤɢɦ ɝɭɛɟɪɧɚɬɨɪɨɦ Ɍɟɯɚɫɚ ɜ ɝɨɞɭ ɩɪɨɤɥɚɦɚɰɢɹ ɨɛ ɷɤɫɩɥɭɚɬɚɰɢɢ ɚɪɟɧ ɞɥɹ ɩɪɨɜɟɞɟɧɢɹ ɤɨɪɪɢɞɵ ɍɝɨɥɨɜɧɵɣ ɤɨɞɟɤɫ ɲɬɚɬɚ Ɍɟɯɚɫ ɨɬ ɝɨɞɚ 9HUQRQ V7H[DV 3HQDO &RGH ɩɪɹɦɨ ɡɚɩɪɟɳɚɥ ©ɤɭɥɚɱɧɵɟ ɛɨɢª ɫɬɚɬɶɹ Ɂɚɤɨɧ ɲɬɚɬɚ Ɍɟɯɚɫ ɨɬʋ ɭɫɬɚɧɚɜɥɢɜɚɥ ɩɨɥɧɨɦɨɱɢɹ ɲɬɚɬɚ ɩɨ ɤɨɧɬɪɨɥɸ ɡɚ ɨɪɝɚɧɢɡɚɰɢɟɣ ɤɭɥɚɱɧɵɯ ɛɨɺɜ ɢ ɫɨɪɟɜɧɨɜɚɧɢɣ ɩɨ ɛɨɪɶɛɟ
ɎɪɚɧɰɢɹɈɞɧɢɦɢ ɢɡ ɩɟɪɜɵɯ ɧɨɪɦɚɬɢɜɧɵɯ ɩɪɚɜɨɜɵɯ ɚɤɬɨɜ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜɨ Ɏɪɚɧɰɢɢ ɹɜɢɥɢɫɶ ɉɪɢɤɚɡ Ɇɢɧɢɫɬɪɚ ɧɚɪɨɞɧɨɝɨ ɩɪɨɫɜɟɳɟɧɢɹ ɢ ɩɨ ɞɟɥɚɦ ɤɭɥɶɬɨɜ ɨɬ ɨ ɩɪɟɩɨɞɚɜɚɧɢɢ ɝɢɦɧɚɫɬɢɤɢ ɜ ɲɤɨɥɟ ɢ Ⱦɟɤɪɟɬ ɨɬ ©Ɉɛ ɨɪɝɚɧɢɡɚɰɢɢ ɡɚɧɹɬɢɣ ɝɢɦɧɚɫɬɢɤɨɣª
ȼ ± ɝɝ ɛɵɥ ɩɪɢɧɹɬ ɰɟɥɵɣ ɪɹɞ ɡɚɤɨɧɨɜ ɜ ɨɫɧɨɜɧɨɦ ± ɤɨɥɥɚɛɨɪɚɰɢɨɧɢɫɬɫɤɢɦ ɉɪɚɜɢɬɟɥɶɫɬɜɨɦ ȼɢɲɢ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜ ɢɯ ɱɢɫɥɟ
Mesa Callejas R.J., Arboleda Sierra R., Gaviria García N., Guzmán Finol K. (VWDGR GH GHVDUUROORGHODVRUJDQL]DFLRQHVGHSRUWLYDVHQ&RORPELD>ɋɨɫɬɨɹɧɢɟɪɚɡɜɢɬɢɹɫɩɨɪɬɢɜɧɵɯ ɨɪɝɚɧɢɡɚɰɢɣ ɜ Ʉɨɥɭɦɛɢɢ@ 8QLYHUVLGDG GH$QWLRTXLD ± 0HGHOOtQ ± S ± 3 ±
+LVWRLUH GH O pGXFDWLRQ SK\VLTXH HW GX VSRUW GH ± >ɂɫɬɨɪɢɹ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɨɛɪɚɡɨɜɚɧɢɹ ɢ ɫɩɨɪɬɚ ɜ ± @ VWDSV IUHH IU OLFHQFH ILFKLHUV B GRF!
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉ ɫɨɡɞɚɧɢɢ Ƚɥɚɜɧɨɝɨ ɤɨɦɢɫɫɚɪɢɚɬɚ ɩɨ ɞɟɥɚɦ ɮɢɡɤɭɥɶɬɭɪɧɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɢ ɫɩɨɪɬɚª Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉ ɫɩɨɪɬɢɜɧɨɦ ɨɫɧɚɳɟɧɢɢª Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉɛ ɨɪɝɚɧɢɡɚɰɢɢ ɫɩɨɪɬɚª ɪɟɝɥɚɦɟɧɬɢɪɨɜɚɜɲɢɣ ɜɨɩɪɨɫɵ ɨɪɝɚɧɢɡɚɰɢɢ ɮɢɡɤɭɥɶɬɭɪɧɨɣ ɢ ɫɩɨɪɬɢɜɧɨɣ ɞɟɹɬɟɥɶɧɨɫɬɢ Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉɛ ɭɱɺɬɟ ɨɯɪɚɧɟ ɢ ɢɫɩɨɥɶɡɨɜɚɧɢɢ ɩɨɦɟɳɟɧɢɣ ɢ ɡɟɦɟɥɶɧɵɯ ɭɱɚɫɬɤɨɜ ɩɪɟɞɧɚɡɧɚɱɟɧɧɵɯ ɞɥɹ ɡɚɧɹɬɢɹ ɫɩɨɪɬɨɦ ɛɚɫɫɟɣɧɨɜ ɢ ɢɧɵɯ ɦɟɫɬ ɞɥɹ ɩɥɚɜɚɧɢɹª ©Ɂɚɤɨɧ Ȼɨɪɨɬɪɚғª Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉɛ ɭɬɜɟɪɠɞɟɧɢɢ ɨɛɪɚɡɰɨɜ ɫɩɨɪɬɢɜɧɨɝɨ ɨɫɧɚɳɟɧɢɹ ɢ ɩɪɟɞɨɫɬɚɜɥɟɧɢɢ ɝɪɚɧɬɨɜ ɩɭɛɥɢɱɧɵɦɢ ɜɥɚɫɬɹɦɢª Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉ ɫɨɡɞɚɧɢɢ Ɏɨɧɞɚ ɫɨɞɟɣɫɬɜɢɹ ɚɜɢɚɰɢɨɧɧɨɦɭ ɫɩɨɪɬɭª ɢ Ⱦɟɤɪɟɬ ɨɬ ɨɬɧɨɫɢɬɟɥɶɧɨ ɩɪɢɦɟɧɟɧɢɹ Ɂɚɤɨɧɚ Ɏɪɚɧɰɢɢ ɨɬ ɭɱɪɟɞɢɜɲɟɝɨ Ɏɨɧɞ ɫɨɞɟɣɫɬɜɢɹ ɚɜɢɚɰɢɨɧɧɨɦɭ ɫɩɨɪɬɭ Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉɛ ɨɛɟɫɩɟɱɟɧɢɢ ɇɚɰɢɨɧɚɥɶɧɨɝɨ ɤɨɦɢɬɟɬɚ ɩɨ ɞɟɥɚɦɫɩɨɪɬɚɫɩɨɪɬɢɜɧɵɯ ɮɟɞɟɪɚɰɢɣɢɚɫɫɨɰɢɚɰɢɣªɁɚɤɨɧɎɪɚɧɰɢɢɨɬ©Ɉ ɮɢɧɚɧɫɢɪɨɜɚɧɢɢ ɪɟɞɚɤɬɨɪɨɜ ɚɩɩɚɪɚɬɚ Ɇɢɧɢɫɬɟɪɫɬɜɚ ɧɚɰɢɨɧɚɥɶɧɨɝɨ ɨɛɪɚɡɨɜɚɧɢɹ ɢ Ƚɥɚɜɧɨɝɨ ɤɨɦɢɫɫɚɪɢɚɬɚ ɩɨɞɟɥɚɦ ɫɩɨɪɬɚª ɪɟɝɥɚɦɟɧɬɢɪɨɜɚɜɲɢɣ ɧɟɤɨɬɨɪɵɟ ɜɨɩɪɨɫɵ ɝɨɫɭɞɚɪɫɬɜɟɧɧɨɣ ɫɥɭɠɛɵ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɉɨɫɬɚɧɨɜɥɟɧɢɟ Ɏɪɚɧɰɭɡɫɤɨɝɨ ɤɨɦɢɬɟɬɚ ɧɚɰɢɨɧɚɥɶɧɨɝɨ ɨɫɜɨɛɨɠɞɟɧɢɹ Ⱥɥɠɢɪ ɨɬ ɨɛ ɨɩɪɟɞɟɥɟɧɢɢ ɜɪɟɦɟɧɧɨɝɨ ɫɬɚɬɭɫɚ ɫɩɨɪɬɢɜɧɵɯ ɢ ɦɨɥɨɞɺɠɧɵɯ ɨɛɴɟɞɢɧɟɧɢɣ Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉ ɫɩɨɪɬɢɜɧɨɦ ɨɫɧɚɳɟɧɢɢ ɧɚ ɦɟɫɬɧɨɦ ɭɪɨɜɧɟª ɜɧɟɫɲɢɣ ɢɡɦɟɧɟɧɢɹ ɜ Ɂɚɤɨɧ Ɏɪɚɧɰɢɢ ɨɬ ©Ɉ ɫɩɨɪɬɢɜɧɨɦ ɨɫɧɚɳɟɧɢɢª ɉɨɫɥɟ ɨɫɜɨɛɨɠɞɟɧɢɹ Ɏɪɚɧɰɢɢ ɩɟɪɜɵɦ ɧɨɪɦɚɬɢɜɧɵɦ ɩɪɚɜɨɜɵɦ ɚɤɬɨɦ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɹɜɢɥɫɹ Ɉɪɞɨɧɚɧɫ ɨɬ ʋ ©Ɉ ɞɟɹɬɟɥɶɧɨɫɬɢ ɫɩɨɪɬɢɜɧɵɯ ɚɫɫɨɰɢɚɰɢɣ ɥɢɝ ɮɟɞɟɪɚɰɢɣ ɢ ɨɛɴɟɞɢɧɟɧɢɣª ɗɬɨ ɛɵɥ ɩɟɪɜɵɣ ɩɪɨɮɢɥɶɧɵɣ ɧɨɪɦɚɬɢɜɧɵɣ ɩɪɚɜɨɜɨɣ ɚɤɬ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜɨ Ɏɪɚɧɰɢɢ
ɉɟɪɜɵɦ ɩɨɥɧɨɜɟɫɧɵɦ ɡɚɤɨɧɨɦ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɹɜɢɥɫɹ Ɂɚɤɨɧ Ɏɪɚɧɰɢɢɨɬ ʋ©Ɉɪɚɡɜɢɬɢɢɮɢɡɢɱɟɫɤɨɝɨɜɨɫɩɢɬɚɧɢɹɢ ɫɩɨɪɬɚª ©Ɂɚɤɨɧ Ɇɚɡɺª ± ©/RL 0D]HDXGª
ɑɟɯɢɹ ɑɟɯɨɫɥɨɜɚɤɢɹ ɉɟɪɜɵɦ ɩɪɨɮɢɥɶɧɵɦ ɧɨɪɦɚɬɢɜɧɵɦ ɩɪɚɜɨɜɵɦ ɚɤɬɨɦ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɹɜɢɥɫɹ Ɂɚɤɨɧ ɑɟɯɨɫɥɨɜɚɤɢɢ ɨɬ ©Ɉ ɝɨɫɭɞɚɪɫɬɜɟɧɧɨɦ ɨɛɟɫɩɟɱɟɧɢɢ ɮɢɡɢɱɟɫɤɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɢ ɫɩɨɪɬɚª ɭɱɪɟɞɢɜɲɢɣ ɇɚɰɢɨɧɚɥɶɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɩɨ ɮɢɡɢɱɟɫɤɨɦɭ ɜɨɫɩɢɬɚɧɢɸ ɢ ɫɩɨɪɬɭ ɋɬɚɬɶɹ ɭɤɚɡɚɧɧɨɝɨ Ɂɚɤɨɧɚ ɭɫɬɚɧɚɜɥɢɜɚɥɚ ɱɬɨ ɡɚɞɚɱɟɣ ɮɢɡɢɱɟɫɤɨɝɨ ɜɨɫɩɢɬɚɧɢɹ ɹɜɥɹɟɬɫɹ ɫɨɯɪɚɧɟɧɢɟ ɢ ɭɥɭɱɲɟɧɢɟ ɡɞɨɪɨɜɶɹ ɧɚɫɟɥɟɧɢɹ ɭɜɟɥɢɱɟɧɢɟ ɢɯ ɮɢɡɢɱɟɫɤɢɯ ɫɢɥ ɢ ɩɪɨɢɡɜɨɞɢɬɟɥɶɧɨɫɬɢ ɬɪɭɞɚ ɱɬɨ ɫɩɨɫɨɛɫɬɜɭɟɬ ɪɚɡɜɢɬɢɸ ɦɭɠɟɫɬɜɚ ɩɪɢ ɧɟɫɟɧɢɢ ɜɨɟɧɧɨɣ ɫɥɭɠɛɵ
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
ɑɢɥɢ Ɉɞɧɢɦ ɢɡ ɩɟɪɜɵɯ ɧɨɪɦɚɬɢɜɧɵɯ ɩɪɚɜɨɜɵɯ ɚɤɬɨɜ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɹɜɢɥɫɹ Ⱦɟɤɪɟɬ ɨɬ ʋ ɜɵɞɟɥɢɜɲɢɣ ɛɸɞɠɟɬɧɵɟ ɫɪɟɞɫɬɜɚ ɧɚ ɮɢɧɚɧɫɢɪɨɜɚɧɢɟ ɫɩɨɪɬɚ ɜ ɑɢɥɢ Ⱦɟɤɪɟɬ ɨɬ ɝɨɞɚ ʋ ɭɱɪɟɞɢɥ ɇɚɰɢɨɧɚɥɶɧɭɸ ɤɨɦɢɫɫɢɸ ɩɨ ɮɢɡɤɭɥɶɬɭɪɧɨɦɭ ɨɛɪɚɡɨɜɚɧɢɸ Ⱦɟɤɪɟɬ ɜɜɨɞɢɜɲɢɣ ɜ ɞɟɣɫɬɜɢɟ Ɂɚɤɨɧ ɨɬ ɝɨɞɚ ʋ ɭɱɪɟɞɢɥ ɍɩɪɚɜɥɟɧɢɟ ɩɨ ɮɢɡɤɭɥɶɬɭɪɧɨɦɭ ɨɛɪɚɡɨɜɚɧɢɸ ɉɟɪɜɵɣ ɩɨɥɧɨɜɟɫɧɵɣ Ɂɚɤɨɧ ɑɢɥɢ ɨ ɫɩɨɪɬɟ ɛɵɥ ɩɪɢɧɹɬ ɬɨɥɶɤɨ ɜ ɝɨɞɭ ± ɷɬɨ ɛɵɥ Ɂɚɤɨɧ ɑɢɥɢ ɨɬ ʋ ©Ɉ ɩɪɚɜɨɜɵɯ ɨɫɧɨɜɚɯ ɫɨɞɟɣɫɬɜɢɹ ɫɩɨɪɬɭª
Ɍɚɤɢɦ ɨɛɪɚɡɨɦ ɦɵ ɢɦɟɟɦ ɧɟɫɤɨɥɶɤɨ ɬɵɫɹɱ ɥɟɬ ɢɫɬɨɪɢɢ ɫɚɦɨɪɟɝɭɥɢɪɨɜɚɧɢɹɜɫɩɨɪɬɟɢɧɟɫɤɨɥɶɤɨɫɨɬɟɧɥɟɬɢɫɬɨɪɢɢɫɩɨɪɬɢɜɧɨɝɨ ɩɪɚɜɚ ɚ ɢɫɬɨɪɢɹ ɩɪɨɮɢɥɶɧɵɯ ɩɨɥɧɨɰɟɧɧɵɯ ɡɚɤɨɧɨɜ ɨ ɫɩɨɪɬɟ ɧɚɫɱɢɬɵɜɚɟɬ ɦɟɧɟɟ ɥɟɬ
Ƚɨɫɭɞɚɪɫɬɜɟɧɧɨɟ ɭɩɪɚɜɥɟɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɍɱɟɛɧɢɤ ɞɥɹ ɦɚɝɢɫɬɪɨɜ
ɉɨɧɹɬɢɟ ɢ ɨɫɨɛɟɧɧɨɫɬɢ OH[ VSRUWLYD
(ɉɨɧɤɢɧ ɂ.ȼ., Ɋɟɞɶɤɢɧɚ Ⱥ.ɂ.)
©Ɉɛɳɟɫɬɜɟɧɧɵɟ ɨɬɧɨɲɟɧɢɹ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɢ ɜ ɱɚɫɬɧɨɫɬɢ ɫɩɨɪɬɢɜɧɚɹ ɞɟɹɬɟɥɶɧɨɫɬɶ ± ɷɬɨ ɰɟɥɵɣ ɦɢɪ ɜ ɰɟɧɬɪɟ ɤɨɬɨɪɨɝɨ ɜɥɚɫɬɜɭɟɬ ɩɪɚɜɢɥɨª ± ɩɢɫɚɥ ɀɟɪɚɥɶɞ ɋɢɦɨɧғ
ɇɟɨɛɯɨɞɢɦɨ ɨɛɪɚɬɢɬɶɫɹ ɤ ɢɫɫɥɟɞɨɜɚɧɢɸ ɩɪɢɪɨɞɵ ɢ ɫɬɪɭɤɬɭɪɵ ɷɬɨɝɨ
©ɜɥɚɫɬɜɭɸɳɟɝɨ ɜ ɦɢɪɟ ɫɩɨɪɬɚ ɩɪɚɜɢɥɚª Ʉɚɤ ɨɛɨɫɧɨɜɚɧɧɨ ɩɢɫɚɥ Ƚ ȼ Ɇɚɥɶɰɟɜ ©ɩɪɚɜɨɜɨɟ ɪɟɝɭɥɢɪɨɜɚɧɢɟ
ɫɨɫɬɚɜɥɹɟɬ ɥɢɲɶ ɱɚɫɬɶ ɫɨɰɢɨ ɧɨɪɦɚɬɢɜɧɨɝɨ ɪɟɝɭɥɢɪɨɜɚɧɢɹ ɨɛɳɟɫɬɜɚ ɚ ɷɬɨ ɩɨɫɥɟɞɧɟɟ ɩɪɟɞɫɬɚɜɥɹɟɬ ɫɩɟɰɢɮɢɱɟɫɤɢɣ ɫɟɤɬɨɪ ɛɨɥɟɟ ɲɢɪɨɤɨɣ ɫɮɟɪɵ ± ɫɨɰɢɚɥɶɧɨɝɨ ɪɟɝɭɥɢɪɨɜɚɧɢɹ ɨɫɭɳɟɫɬɜɥɹɟɦɨɝɨ ɧɚ ɛɚɡɟ ɦɧɨɠɟɫɬɜɚ ɭɩɨɪɹɞɨɱɢɜɚɸɳɢɯ ɮɚɤɬɨɪɨɜ ɞɚɥɟɤɨ ɧɟ ɜɫɟɝɞɚ ɫɜɨɞɢɦɵɯ ɤ ɧɨɪɦɟª
ɋɢɫɬɟɦɚ ɧɨɪɦɚɬɢɜɧɨɣ ɪɟɝɥɚɦɟɧɬɚɰɢɢ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɜɤɥɸɱɚɟɬ ɞɜɚ
ɤɪɭɩɧɵɯ ɢ ɫɚɦɨɫɬɨɹɬɟɥɶɧɵɯ ɫɟɝɦɟɧɬɚ ɤɨɦɩɥɟɤɫɚ ɫɩɨɪɬɢɜɧɨɟ ɩɪɚɜɨ ± ɤɨɦɩɥɟɤɫ ɧɨɪɦɚɬɢɜɧɨ ɩɪɚɜɨɜɨɝɨ
ɪɟɚɥɢɡɭɟɦɨɝɨ ɨɪɝɚɧɚɦɢ ɩɭɛɥɢɱɧɨɣ ɜɥɚɫɬɢ ɪɟɝɭɥɢɪɨɜɚɧɢɹ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ
©OH[ VSRUWLYDª ± ɤɨɦɩɥɟɤɫ ɢɧɨɝɨ ɩɨɦɢɦɨ ɩɪɚɜɨɜɨɝɨ ɧɨɪɦɚɬɢɜɧɨɝɨ ɪɟɝɭɥɢɪɨɜɚɧɢɹ ɢɧɵɟ ɧɚɢɦɟɧɨɜɚɧɢɹ ± ɫɚɦɨɪɟɝɭɥɢɪɨɜɚɧɢɟ ɨɬɧɨɲɟɧɢɣ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɫɭɛɴɟɤɬɚɦɢ ɫɩɨɪɬɚ ɥɨɤɚɥɶɧɨ ɤɨɪɩɨɪɚɬɢɜɧɨɟ ɪɟɝɭɥɢɪɨɜɚɧɢɟ ɜ ɫɮɟɪɟ ɫɩɨɪɬɚ ɢ ɬ ɞ
ɂɦɟɸɬɫɹ ɪɚɡɥɢɱɧɵɟ ɬɨɱɤɢ ɡɪɟɧɢɹ ɧɚ OH[ VSRUWLYD ɜɩɥɨɬɶ ɞɨ ɩɨɥɧɨɝɨ ɨɬɪɢɰɚɧɢɹ ɫɭɳɟɫɬɜɨɜɚɧɢɹ ɷɬɨɣ ɜɧɟɩɪɚɜɨɜɨɣ ɷɤɫɬɪɚ ɩɪɚɜɨɜɨɣ ɧɨɪɦɚɬɢɜɧɨɣ ɫɢɫɬɟɦɵ
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