Материал: ABC-of-Rheumatology-ABC-Series-

creatine kinase 158 CREST syndrome 125

Crithidia luciliae 160 Crohn’s disease 83 cryoglobulinaemia 150 cryopyrinopathies 105 cubital tunnel syndrome 9

cutaneous scleroderma 124–5 cyclic neutropenia 105 cyclophosphamide 77, 97, 121, 154 cyclosporin A 96–7

dactylitis 80, 82 daylight sign 43

De Quervain’s tenosynovitis 7, 8 dermatitis 138, 139

dermatomyositis (DMS) 118, 136, 137 children 89, 102, 103

diabetes cheiropathy 140 lower limbs 44 upper limbs 10

disc herniation 21–2, 23, 25–6 discoid lupus 115, 137

DMARDs (disease-modifying antirheumatic drugs) 77, 84

DNA antibodies 160 duloxetine 50 Dupuytren’s contracture 9

Ehlers-Danlos syndrome 101

elbows, disorders and conditions 19–20, 72 ELISA tests 159–61

enteropathic arthritis 83 enthesitis 80, 84, 94 epicleritis 73 epidemiology

fibromyalgia 169 low back pain 168–9 osteoarthritis 168

rheumatoid arthritis 167–8 shoulder pain 169

systemic lupus erythematosus 115, 170 Epstein-Barr virus 168

ESR (erythrocyte sedimentation rate) 91, 158

etanercept 154 children 95, 96, 97

evidence–based treatments 3–4 Ewing’s sarcoma 36

exercise 3

in pain management 57 preparation routines 146 recommendations 146–7 see also sports medicine

expert patient programmes 1–2 extended roles 1, 165

extended–scope physiotherapists (ESPs) 165

extractable nuclear antigens (ENAs) antibodies 160

eye conditions

in ankylosing spondylitis 80 in psoriatic arthritis 82

in reactive arthritis 83

in rheumatoid arthritis 73 in Sjögren’s syndrome 118

facial rashes

SLE 115, 137, 138–9 see also skin conditions

falls prevention 70 feet 38–48

characteristics and anatomy 38, 39 childhood conditions 38–9 forefoot pain 39–41

heel pain 41–2

plantar fascia affections 41 systemic arthropathies 43–7 treatments and management 45–6

Felty’s syndrome 156 fibromyalgia syndrome 47–50, 140

epidemiology 169 Finkelstein’s test 7 fish oils 127

5HT reuptake inhibitors 127 flare reactions 73

flat feet 100–1 flexor tendonitis 7

flexor tenosynovitis 5–6

fluorescent microsphere technology 159 foot pain see feet

fractures

pain management 70 risk assessments 67–9 Freiberg’s infraction 40

frozen shoulder 17–18

gait

children 99 limping 99–100

gamolenic acid 127 ganglions 10 Garrod’s pads 9

gastrointestinal disorders 83

gender and incidence/prevalence studies 170 osteoarthritis 52, 53

general practitioners 164

special interest practitioners (GPwSIs) 165 genetic factors

ankylosing spondylitis 169 giant cell arteritis 170 osteoarthritis 53, 168 polymyalgia rheumatica 170 psoriatic arthritis 169 rheumatoid arthritis 71, 167

systemic lupus erythematosus (SLE) 170 genetic markers 161

giant cell arteritis 107–13 clinical features 108, 109 epidemiology 170 histopathology 109 investigations 110–12 treatments 112–13

ginko biloba 127

glenohumeral joint arthritides 18 global perspectives 4 glucosamine 57

gold 77

golfer’s elbow 19–20 Gottron’s rash 102 gout 59–64

causes and risk factors 59–60, 170 clinical features and investigations 61–2 general management and treatments 62–4

epidemiology 170 feet 44

hand and wrist pain 9 GPs 2, 164

GPwSIs 165 groin pain 30–1 growing pains 100 guanethidine 132

haematological investigations in adults 156–7

in children 91 haemolytic anaemia 157 hands

causes of pain 6 functional anatomy 5, 6

osteoarthritic conditions 8–9 other conditions 10–11

systemic disorders 9–10, 72, 73, 74 tendon conditions 5–8

Heberden’s nodes 8 heel pain 41–2

Henoch-Schönlein purpura (HSP) 89, 104, 105, 150

hepatic function investigations 91, 157–8 hip fracture 30

hip pain

adults 29–31 children 28–9 management 31

HLA (human leucocyte antigen) associations 71, 79–80, 161, 167, 169–70

HRT (hormone replacement therapy) 69 hyaluronan preparations 57 hydroxychloroquine 77, 96 hyerimmunoglobulinaemia D 105 hypermobility 101

hyperuricaemia 59–61

and cardiovascular disease 61 and gout 60–1

hypothyroidism 140

ICPs (integrated-care pathways) 163 idiopathic pain syndromes, children 90–1 iliopsoas bursitis 30

iliotibial band friction syndrome 34 immunofluorescence tests 134–5, 159–60, 161 immunoglobulins 91, 154, 159, 161 immunological investigations

adults 159–61 children 91

infections 83, 101–2

tests and investigations 162

see also reactive arthritis; septic arthritis infective endocarditis 152

inflammatory back pain 79–80 see also ankylosing spondylitis

inflammatory bowel disease (IBD) 83 infliximab 77–8, 96, 97 integrated-care pathways (ICPs) 163 iritis 80

iron-deficient anaemia 157 irritable hip 28

ischial bursitis 31

Jacoud’s arthropahy 116

Jessner’s lesions 139

joint aspiration 61 joint hypermobility 101 joint replacement 57–8

juvenile dermatomyositis (DMS) 89, 102, 103 juvenile idiopathic arthritis 29, 38, 85–97, 102

classification and types 91–4 diagnosis and clinical signs 85–7 differential diagnosis 87–91 investigations 91

treatments 94–7

Kawasaki disease 89, 104, 149 Kienböck disease 10

kineret 97 knee pain 32–6

children 99–100 investigations 33, 36 older people 34–5

overuse and sports injuries 33–4 surgery 35

systemic diseases 35–6 trauma 32–3

laboratory tests 156–62 leflunomide 77

leg dermatomes 24 Lesch-Nyhan syndrome 62 leucocytosis 156 leucopenia 156

leukaemia, lymphoblastic 89–90 limping, children 99–100 livedo reticularis 152

liver function tests 91, 157–8 low back pain 21–6

causes 21 conditions 21–3 idiopathic 23

investigations and assessment 23–5 red flag signs 25

treatments 25–6 lumbar spondylosis 21 lung fibrosis 128 lupus erythematosus

anticoagulant tests 160–1 drug-induced 138–9 systemic 114–21, 136–7

lupus vulgaris 139 Lyme disease 162

lymphoblastic leukaemia 89–90 lymphoma 90

Malar rash 115 mallet finger 8 march fracture 39

Marfan’s syndrome 101 median nerve compression 6 Mediterranean fever 105 megoblastic anaemia 157 meniscus injuries 32, 33 meralgia paraesthetica 31 metastases, hips 30 metatarsal pain 39–41 methotrexate 77

children 95, 96 microbiology investigations 162 Milwaukee shoulder 18, 64 minocycline 77

monoarticular flare 73 Morton’s neuroma 39 Muckle-Wells syndrome 105

multidisciplinary care 1–3, 105, 163–6

nail pitting 82

National Rheumatoid Arthritis Society 166 neck pain

anatomical features 12 clinical evaluation 12–13 differential diagnosis 13

disorders and conditions 13–14 treatments 14–15

Neisseria infections 152 neoplasia, osteomas 101 nerve blocks 132–3

nerve-root compression 13–14, 22–3, 26 neuroblastomas 90

nodal osteoarthritis 8

NSAIDs (non-steroidal anti-inflammatory drugs) 4, 57, 62, 76

contra-indications 4 for children 94–5

nurse specialists 1, 2, 165 nutraceuticals 57

obesity 53, 59, 60, 168 occupational therapists 165 olecranon bursitis 20 oligoarthritis 84, 92–3 orthoses 45, 57 Osgood-Schlatter disease 100–1 osteoarthritis 51–8

causes and risk factors 53 characteristics and presentations 51–3 clinical examination 54–5

diagnosis 55 distributions 54

general management and treatments 55–8

epidemiology 168 feet 43

hips 29–30 knees 34–5

osteochondral fractures 33 osteochondritis 100–1 osteomas 101 osteomyelitis

adults 36 children 88, 105

osteonecrosis 10 osteopathy 26 osteoporosis 65–70

causes and pathophysiology 65 classification and epidemiology 65–6, 168 fracture risk assessments 67–9

guidance and treatments 69–70 Ottawa ankle rules 145

pacing activities 49 Paget’s disease 30 pain

cycles 49

drug therapies 50, 57, 69–70 epidemiology 168–9 influencing factors 49 management 3–4, 49–50

risk factors 168–9 syndromes in children 90–1

paracetamol 57 parathyroid hormone 69

partnership working see multidisciplinary care; shared-care practices

patellar tendonopathy 33–4 patient care

guidance and standards 163 referral procedures 2, 164 screening and early recognition 164 team approaches 1–3, 163–6

patient education 1–2 penicillamine 77 pericarditis 73 Perthes’ disease 28

pes anserine bursitis 34 Peyronie’s disease 9 Phalen’s test 6 photosensitivity 138 physical activities

pacing 49

see also exercise physiotherapists 3, 165 plantar calcaneal bursitis 41–2 plantar fascia affections 41

plantar metatarsal bursitis 40–1 platelet abnormalities 156 podiatry 165–6

policeman’s heel 41–2 polyangiitis 149 polyarteritis nodosa 148–9 polyarthritis 93

polymyalgia rheumatica 107–13 clinical features 108 epidemiology 170 histopathology 109–10 investigations 110–12 treatments 112–13

polymyositis 118, 136 positive prayer sign 10, 140 prayer sign 10, 140 prednisolone 63, 96, 154 pregabalin 50

primary care and musculoskeletal problems

diagnosis and recognition 2, 3, 164 incidence 2

management approaches 3–4, 163–6

referral to secondary care 2, 164 team working 163–6 treatments 3–4

prolapsed disc 21–2, 23 pronation, feet 38–9 prosthetic joints 57–8 pseudogout 63

hand and wrist pain 9, 11 psoas tendon abnormalities 30 psoriatic arthritis 82

clinical signs 75, 82 epidemiology 169–70 feet 43–4

hand pain 9 in children 93

psychosocial factors and pain 3 pulmonary hypertension 127–8

raloxifene 69

Raynaud’s phenomenon 10, 118, 121, 123–4, 136 treatments 127

see also scleroderma syndromes reactive arthritis 83

children 88

red flag disorders 3 knees 36

low back 25

neck and shoulder 13–14 in children 99

in rheumatoid arthritis 72–3 referral procedures 2, 164

reflex sympathetic dystrophy 130–3 causes 130–1

diagnosis 131–2 treatments 132–3

see also complex regional pain syndromes Reiter’s syndrome 44, 83

renal function tests 158 repetitive strain injuries 8 rheumatoid arthritis 71–5

clinical features and pathogenesis 71–3 complications and red flag signs 72–3 differential diagnosis 74–5 epidemiology 167–8, 170 examination and investigations 73–4 feet 40, 43, 45–6

hands 9 knees 36

management guidelines 164 risk factors 167

treatments 76–8 rheumatoid factor 91, 159 rheumatologists 166 risedronate 69

rituximab 78, 154 rosacea 138, 139

rotator cuff disease 16–17 Russell’s viper venom time 160–1

sacroiliitis 84 Salmonella infections 83 SAPHO syndrome 18 sausage toe 44, 80–1

scaphoid bone fractures 10–11 sciatica 21, 24–5

scleritis 73

scleroderma renal crisis (SRC) 128 scleroderma syndromes 123–9, 136

children 89, 103–4 epidemiology 170

organ-based complications 127–9 seborrhoeic dermatitis 138, 139 secondary care 166

referral procedures 2, 164

selective oestrogen receptor modulators 69

self-help measures 1–2 support agencies 166

septic arthritis 11, 73 hips 28, 30

in children 88, 101–2 investigations 162

seredrin 127

service provisions 1–3, 163 child-adult transitions 105

multidisciplinary care approaches 1–3, 105, 163–6

referral procedures 2, 164 standards and guidance 163

Sever’s disease 41 shared-care practices 1–3 shoulder pain

anatomy 12, 13

clinical evaluation 12–13 differential diagnosis 15 disorders and conditions 15–19 epidemiological factors 169 instability 18

Sjögren’s syndrome 118, 136 skin conditions

chronic infantile neurological cutaneous arthritis 99

dermatomyositis 89, 102, 103, 118, 136, 137 Henoch-Schönlein purpura (HSP) 89, 104,

105, 150

psoriatic arthritis 43–4, 82, 93, 169–70 sclerodermas 89, 103–4, 123–9, 136 SLE 115–18, 137

systemic arthritis 92 vasculitis 104, 148–54

SLE see systemic lupus erythematosus slipped upper femoral epiphysis 28 smoking 167, 168, 169

specialist nurse roles 1, 2, 165 spinal cord stimulation 133 spine

anatomical features 22–3

nerve root compressions 13–14, 22–3, 26 stenosis 22–3, 26

see also ankylosing spondylitis; low back pain; neck

spondoylolisthesis 22, 23 spondyloarthritides 25, 79–84

ankylosing spondylitis 43–4, 79–82 enteropathic arthritis 83

psoriatic arthritis 9, 43–4, 75, 82 reactive arthritis 83, 88 undifferentiated 83–4 treatments 84

spondylosis, lumbar 21 sports medicine 142–7

assessment and investigations 142–3 common injuries 145–6 management 143–5 recommendations for exercise 146–7

standards of care 163 stem-cell transplants 97

sternoclavicular joint disorders 18 steroids

adults 3–4, 57, 63, 76, 77, 154 children 95–6 intra-articular 3–4, 11

Stickler’s syndrome 101 straight leg raise test 24

Streptobacilli infections 152 stress fractures 146

feet 39

strontium ranelate 69 Sudeck’s atrophy 44 sulfasalazine 77

children 95, 96 supination, feet 38–9

support agencies 166 surgery

arthroscopic debridement 57 decompression procedures 7 joint replacements 35, 57–8 in OA 35, 57–8

in RA 48, 78

synovial fluid analysis 74, 91 synovitis

feet 40 hands 5–8 hips 28

systemic lupus erythematosus (SLE) 114–21, 136–7

causes and prevalence 114–15 clinical presentations 115–18, 137 epidemiology 115, 170

and infections 140 investigations 119–20, 159–61 management 120–1

in children 88–9, 102 in neonates 118

systemic sclerosis 136, 137

see also scleroderma syndromes

tacrolimus 77

Takayasu’s arteritis 104, 154

tendon problems, hand and wrist 5–8 tennis elbow 19–20

tenosynovitis 7–8 teriparatide 69

thoracic outlet syndrome 19 thrombocytopenia 156 thumb osteoarthritis 8–9 thumb tenosynovitis 7 Tinel’s sign 6, 9

tophaceous gout 9 treatment principles

evidence–based practice 3–4 global perspectives 4

triamcinolone hexacetonide 95 tricyclic antidepressants 50 trigger finger 7

trochanteric bursitis 30

tumour necrosis factor antagonists 77–8, 84, 154 children 94–5, 96, 97

UK Arthritis and Musculoskeletal Alliance (ARMA) 163

ulcerative colitis 83

ulnar nerve compression 9

undifferentiated connective tissue disease 135 upper limb pain 10

urate stones 62, 158 uric acid tests 157, 158 uveitis 80, 82

valgus heel 41 vasculitis 148–54

children 104

conditions and types 148–50 differential diagnosis 152–4 investigations 150–2 treatments 154

see also giant cell arteritis; Takayasu’s arteritis virus infections 162, 168

investigations 162